IL-10-producing, ST2-expressing Foxp3(+) T cells in multiple sclerosis brain lesions

Stephanie Elizabeth Johanna Zandee; Richard Anthony O'Connor; Iris Mair; Melanie Dawn Leech; Anna Williams; Stephen Mark Anderton

doi:10.1038/icb.2017.3

IL-10-producing, ST2-expressing Foxp3(+) T cells in multiple sclerosis brain lesions

Stephanie Elizabeth Johanna Zandee, Richard Anthony O'Connor, Iris Mair, Melanie Dawn Leech, Anna Williams, Stephen Mark Anderton

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

CD4(+)Foxp3(+) T regulatory (Treg) cells provide a key defence against inflammatory disease, but also have an ability to produce pro-inflammatory cytokines. The evidence for these two possibilities in multiple sclerosis (MS) is controversial. However, this has largely been based on studies of circulating Treg cells derived from peripheral blood, rather than the central nervous system. We show that Foxp3(+) cells in the brains of MS patients predominantly produce interleukin-10 (IL-10) and show high expression of the IL-33 receptor ST2 (associated with potent Treg function), indicating that Treg in the inflamed brain maintain their suppressive function.Immunology and Cell Biology advance online publication, 7 February 2017; doi:10.1038/icb.2017.3.

Original language	English
Journal	Immunology & Cell Biology
DOIs	https://doi.org/10.1038/icb.2017.3
Publication status	Published - 7 Feb 2017

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10.1038/icb.2017.3

Zandee et al REVISED submitted to ICB 19-12-2016Accepted author manuscript, 770 KB

In situ studies on FoxP3* regulatory T cells in CNS autoimmune disease
Anderton, S.
EU other
1/05/13 → 1/05/15
Project: Research
PROBING REGULATORY T CELLS IN MULTIPLE SCLEROSIS BRAIN
Anderton, S. & Williams, A.
UK central government bodies/local authorities, health and hospital authorities
1/01/12 → 30/06/13
Project: Research
Immune cell interactions in the inflammed CNS
Anderton, S. & O'Connor, R.
MRC
1/04/09 → 30/09/14
Project: Research

Cite this

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title = "IL-10-producing, ST2-expressing Foxp3(+) T cells in multiple sclerosis brain lesions",

abstract = "CD4(+)Foxp3(+) T regulatory (Treg) cells provide a key defence against inflammatory disease, but also have an ability to produce pro-inflammatory cytokines. The evidence for these two possibilities in multiple sclerosis (MS) is controversial. However, this has largely been based on studies of circulating Treg cells derived from peripheral blood, rather than the central nervous system. We show that Foxp3(+) cells in the brains of MS patients predominantly produce interleukin-10 (IL-10) and show high expression of the IL-33 receptor ST2 (associated with potent Treg function), indicating that Treg in the inflamed brain maintain their suppressive function.Immunology and Cell Biology advance online publication, 7 February 2017; doi:10.1038/icb.2017.3.",

author = "Zandee, {Stephanie Elizabeth Johanna} and O'Connor, {Richard Anthony} and Iris Mair and Leech, {Melanie Dawn} and Anna Williams and Anderton, {Stephen Mark}",

year = "2017",

month = feb,

day = "7",

doi = "10.1038/icb.2017.3",

language = "English",

journal = "Immunology & Cell Biology",

issn = "0818-9641",

publisher = "Wiley",

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T1 - IL-10-producing, ST2-expressing Foxp3(+) T cells in multiple sclerosis brain lesions

AU - Zandee, Stephanie Elizabeth Johanna

AU - O'Connor, Richard Anthony

AU - Mair, Iris

AU - Leech, Melanie Dawn

AU - Williams, Anna

AU - Anderton, Stephen Mark

PY - 2017/2/7

Y1 - 2017/2/7

N2 - CD4(+)Foxp3(+) T regulatory (Treg) cells provide a key defence against inflammatory disease, but also have an ability to produce pro-inflammatory cytokines. The evidence for these two possibilities in multiple sclerosis (MS) is controversial. However, this has largely been based on studies of circulating Treg cells derived from peripheral blood, rather than the central nervous system. We show that Foxp3(+) cells in the brains of MS patients predominantly produce interleukin-10 (IL-10) and show high expression of the IL-33 receptor ST2 (associated with potent Treg function), indicating that Treg in the inflamed brain maintain their suppressive function.Immunology and Cell Biology advance online publication, 7 February 2017; doi:10.1038/icb.2017.3.

AB - CD4(+)Foxp3(+) T regulatory (Treg) cells provide a key defence against inflammatory disease, but also have an ability to produce pro-inflammatory cytokines. The evidence for these two possibilities in multiple sclerosis (MS) is controversial. However, this has largely been based on studies of circulating Treg cells derived from peripheral blood, rather than the central nervous system. We show that Foxp3(+) cells in the brains of MS patients predominantly produce interleukin-10 (IL-10) and show high expression of the IL-33 receptor ST2 (associated with potent Treg function), indicating that Treg in the inflamed brain maintain their suppressive function.Immunology and Cell Biology advance online publication, 7 February 2017; doi:10.1038/icb.2017.3.

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DO - 10.1038/icb.2017.3

M3 - Article

C2 - 28169287

SN - 0818-9641

JO - Immunology & Cell Biology

JF - Immunology & Cell Biology

ER -

IL-10-producing, ST2-expressing Foxp3(+) T cells in multiple sclerosis brain lesions

Abstract / Description of output

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Projects

In situ studies on FoxP3* regulatory T cells in CNS autoimmune disease

PROBING REGULATORY T CELLS IN MULTIPLE SCLEROSIS BRAIN

Immune cell interactions in the inflammed CNS

Cite this