IL-10-producing, ST2-expressing Foxp3(+) T cells in multiple sclerosis brain lesions

Stephanie Elizabeth Johanna Zandee, Richard Anthony O'Connor, Iris Mair, Melanie Dawn Leech, Anna Williams, Stephen Mark Anderton

Research output: Contribution to journalArticlepeer-review

Abstract

CD4(+)Foxp3(+) T regulatory (Treg) cells provide a key defence against inflammatory disease, but also have an ability to produce pro-inflammatory cytokines. The evidence for these two possibilities in multiple sclerosis (MS) is controversial. However, this has largely been based on studies of circulating Treg cells derived from peripheral blood, rather than the central nervous system. We show that Foxp3(+) cells in the brains of MS patients predominantly produce interleukin-10 (IL-10) and show high expression of the IL-33 receptor ST2 (associated with potent Treg function), indicating that Treg in the inflamed brain maintain their suppressive function.Immunology and Cell Biology advance online publication, 7 February 2017; doi:10.1038/icb.2017.3.

Original languageEnglish
JournalImmunology and Cell Biology
DOIs
Publication statusPublished - 7 Feb 2017

Fingerprint Dive into the research topics of 'IL-10-producing, ST2-expressing Foxp3(+) T cells in multiple sclerosis brain lesions'. Together they form a unique fingerprint.

Cite this