Projects per year
of the antimicrobial / host defence peptide human beta defensin 2 (hBD2) was foundto be the mechanism underpinning this protective effect. Endogenous hBD2expression was required and sufficient for protection against V8 protease-mediatedintegrity damage, and exogenous application of hBD2 was protective. This novelmodulatory property of hBD2, unrelated to antibacterial effects, gives newsignificance to the defective induction of hBD2 in the barrier-defective skin lesions ofAD, and indicates novel therapeutic potential.
FingerprintDive into the research topics of 'IL-1beta-induced protection of keratinocytes against Staphylococcus aureus-secreted proteases is mediated by human beta defensin 2'. Together they form a unique fingerprint.
- 1 Finished
1/04/11 → 31/03/17