Imaging biomarkers of angiogenesis and the microvascular environment in cerebral tumours

G Thompson, S J Mills, D J Coope, J P B O'Connor, A Jackson

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Conventional contrast-enhanced CT and MRI are now in routine clinical use for the diagnosis, treatment and monitoring of diseases in the brain. The presence of contrast enhancement is a proxy for the pathological changes that occur in the normally highly regulated brain vasculature and blood-brain barrier. With recognition of the limitations of these techniques, and a greater appreciation for the nuanced mechanisms of microvascular change in a variety of pathological processes, novel techniques are under investigation for their utility in further interrogating the microvasculature of the brain. This is particularly important in tumours, where the reliance on angiogenesis (new vessel formation) is crucial for tumour growth, and the resulting microvascular configuration and derangement has profound implications for diagnosis, treatment and monitoring. In addition, novel therapeutic approaches that seek to directly modify the microvasculature require more sensitive and specific biological markers of baseline tumour behaviour and response. The currently used imaging biomarkers of angiogenesis and brain tumour microvascular environment are reviewed.

Original languageEnglish
Pages (from-to)S127-44
JournalBritish Journal of Radiology
Volume84 Spec No 2
DOIs
Publication statusPublished - Dec 2011

Keywords

  • Biomarkers, Tumor
  • Brain Mapping
  • Brain Neoplasms
  • Contrast Media
  • Diagnosis, Differential
  • Diagnostic Imaging
  • Humans
  • Image Enhancement
  • Magnetic Resonance Imaging
  • Microvessels
  • Neovascularization, Pathologic
  • Positron-Emission Tomography
  • Tomography, Emission-Computed, Single-Photon
  • Tomography, X-Ray Computed

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