Abstract / Description of output
Calcification is one of the body’s primary responses to injury and a key pathological feature of cardiovascular disease. Calcification activity can now be imaged using 18F-fluoride PET/CT or MR/PET, providing different information compared to established macroscopic calcification imaged with computed tomography. Indeed 18F-fluoride PET has now been explored in a wide range of conditions including aortic stenosis, coronary and carotid atherosclerosis, peripheral vascular disease, aortic aneurysm disease, erectile dysfunction, and bioprosthetic valve disease, offering a marker of vascular injury and disease activity in each condition studied. We will here review the current literature investigating 18F-fluoride PET in cardiovascular disease and discuss how this novel imaging approach might advance our pathophysiological understanding and ultimately improve patient care.