Imaging Cardiovascular Calcification Activity with 18F-Fluoride PET

Evangelos Tzolos, Marc R Dweck

Research output: Chapter in Book/Report/Conference proceedingChapter (peer-reviewed)peer-review

Abstract / Description of output

Calcification is one of the body’s primary responses to injury and a key pathological feature of cardiovascular disease. Calcification activity can now be imaged using 18F-fluoride PET/CT or MR/PET, providing different information compared to established macroscopic calcification imaged with computed tomography. Indeed 18F-fluoride PET has now been explored in a wide range of conditions including aortic stenosis, coronary and carotid atherosclerosis, peripheral vascular disease, aortic aneurysm disease, erectile dysfunction, and bioprosthetic valve disease, offering a marker of vascular injury and disease activity in each condition studied. We will here review the current literature investigating 18F-fluoride PET in cardiovascular disease and discuss how this novel imaging approach might advance our pathophysiological understanding and ultimately improve patient care.
Original languageEnglish
Title of host publicationCardiovascular Calcification and Bone Mineralization
Number of pages440
Publication statusPublished - 2 Jul 2020


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