Imaging diagnosis of Crohn disease

Vincenzo Migaleddu, Emilio Quaia, Domenico Scanu, Danilo Sirigu, Michele Bertolotto, Girolamo Campisi, Giuseppe Virgilio

Research output: Contribution to journalArticlepeer-review


Improvements in the ultrasound examination of bowel disease have registered in the last years the introduction of new technologies regarding high frequency probes (US), highly sensitive color or power Doppler units (CD-US), and the development of new non-linear technologies that optimize detection of microbubbles contrast agents responses. Contrast-enhanced ultrasound (CE-US) most importantly increases the results in sonographic evaluation of Crohn disease inflammatory activity. CE-US has become an imaging modality routinely employed in the clinical practice for the evaluation of parenchymal organs due to the introduction of new generation microbubble contrast agents which persist in the bloodstream for several minutes after intravenous injection. The availability of high frequency dedicated contrast-specific US techniques provide accurate depiction of small bowel wall perfusion due to the extremely high sensitivity of non-linear signals produced by microbubble insonation. In Crohn's disease, CE-US may characterize the bowel wall thickness by differentiating fibrosis from edema and may grade the inflammatory disease activity by assessing the presence and distribution of vascularity within the layers of the bowel wall (submucosa alone or the entire bowel wall). Peri-intestinal inflammatory involvement can be also characterized. CE-US can provide prognostic data concerning clinical recurrence of the inflammatory disease and evaluate the efficacy of drugs treatments.

Translated title of the contributionImaging diagnosis of Crohn disease
Original languageItalian
Pages (from-to)185-93
Number of pages9
JournalRecenti progressi in medicina
Issue number5
Publication statusPublished - May 2010


  • Contrast Media
  • Crohn Disease
  • Humans
  • Microbubbles
  • Predictive Value of Tests
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Ultrasonography, Doppler, Color


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