Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride

Nicola Kielland, Marc Vendrell, Rodolfo Lavilla*, Young-Tae Chang

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Histamine is a biogenic amine with fundamental roles in circulatory and immune systems. We report a fluorescent small molecule (Histamine Blue) for imaging intracellular histamine in live basophils and macrophages. Histamine Blue is a fluorescent mesoionic acid fluoride that turns on upon reaction with histamine. The selective response of Histamine Blue enabled the visualization of intracellular histamine under different physiological conditions.

Original languageEnglish
Pages (from-to)7401-7403
Number of pages3
JournalChemical Communications
Volume48
Issue number59
DOIs
Publication statusPublished - 2012

Keywords

  • SAMPLES
  • SYSTEM
  • AMINES
  • CELLS

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