Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride

Nicola Kielland; Marc Vendrell; Rodolfo Lavilla; Young-Tae Chang

doi:10.1039/c2cc32292g

Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride

Nicola Kielland, Marc Vendrell, Rodolfo Lavilla^*, Young-Tae Chang

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Histamine is a biogenic amine with fundamental roles in circulatory and immune systems. We report a fluorescent small molecule (Histamine Blue) for imaging intracellular histamine in live basophils and macrophages. Histamine Blue is a fluorescent mesoionic acid fluoride that turns on upon reaction with histamine. The selective response of Histamine Blue enabled the visualization of intracellular histamine under different physiological conditions.

Original language	English
Pages (from-to)	7401-7403
Number of pages	3
Journal	Chemical Communications
Volume	48
Issue number	59
DOIs	https://doi.org/10.1039/c2cc32292g
Publication status	Published - 2012

Keywords / Materials (for Non-textual outputs)

SAMPLES
SYSTEM
AMINES
CELLS

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10.1039/c2cc32292g

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title = "Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride",

abstract = "Histamine is a biogenic amine with fundamental roles in circulatory and immune systems. We report a fluorescent small molecule (Histamine Blue) for imaging intracellular histamine in live basophils and macrophages. Histamine Blue is a fluorescent mesoionic acid fluoride that turns on upon reaction with histamine. The selective response of Histamine Blue enabled the visualization of intracellular histamine under different physiological conditions.",

keywords = "SAMPLES, SYSTEM, AMINES, CELLS",

author = "Nicola Kielland and Marc Vendrell and Rodolfo Lavilla and Young-Tae Chang",

year = "2012",

doi = "10.1039/c2cc32292g",

language = "English",

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TY - JOUR

T1 - Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride

AU - Kielland, Nicola

AU - Vendrell, Marc

AU - Lavilla, Rodolfo

AU - Chang, Young-Tae

PY - 2012

Y1 - 2012

N2 - Histamine is a biogenic amine with fundamental roles in circulatory and immune systems. We report a fluorescent small molecule (Histamine Blue) for imaging intracellular histamine in live basophils and macrophages. Histamine Blue is a fluorescent mesoionic acid fluoride that turns on upon reaction with histamine. The selective response of Histamine Blue enabled the visualization of intracellular histamine under different physiological conditions.

AB - Histamine is a biogenic amine with fundamental roles in circulatory and immune systems. We report a fluorescent small molecule (Histamine Blue) for imaging intracellular histamine in live basophils and macrophages. Histamine Blue is a fluorescent mesoionic acid fluoride that turns on upon reaction with histamine. The selective response of Histamine Blue enabled the visualization of intracellular histamine under different physiological conditions.

KW - SAMPLES

KW - SYSTEM

KW - AMINES

KW - CELLS

U2 - 10.1039/c2cc32292g

DO - 10.1039/c2cc32292g

M3 - Article

SN - 1359-7345

VL - 48

SP - 7401

EP - 7403

JO - Chemical Communications

JF - Chemical Communications

IS - 59

ER -

Imaging histamine in live basophils and macrophages with a fluorescent mesoionic acid fluoride

Abstract

Keywords / Materials (for Non-textual outputs)

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