Imaging of brain tumors: perfusion/permeability

Gerard Thompson, Samantha Jane Mills, Stavros Michael Stivaros, Alan Jackson

Research output: Contribution to journalLiterature reviewpeer-review


The use of biomarkers of microvascular structure and function from perfusion and permeability imaging is now well established in neuro-oncological research. There remain significant challenges to be overcome before these techniques and related biomarkers can find general clinical acceptance. Core to this is the standardization of acquisition and processing protocols for robust use across multiple clinical sites. The potential clinical benefits of these approaches are already becoming clear, particularly in the setting of novel antiangiogenic therapies. With an increasing body of evidence in the scientific literature, and with a steadily falling barrier to entry, the coming decade should see rapid developments in imaging biomarkers, and facilitate their transition into routine clinical practice.

Original languageEnglish
Pages (from-to)337-53
Number of pages17
JournalNeuroimaging clinics of North America
Issue number3
Publication statusPublished - Aug 2010


  • Biomarkers, Tumor
  • Brain
  • Brain Neoplasms
  • Capillary Permeability
  • Contrast Media
  • Diagnosis, Differential
  • Glioma
  • Humans
  • Lymphoma
  • Magnetic Resonance Angiography
  • Magnetic Resonance Imaging
  • Neovascularization, Pathologic
  • Tomography, X-Ray Computed


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