Imaging Phenotypes of Chronic Obstructive Pulmonary Disease

Julia Ley-Zaporozhan, Edwin J. R. van Beek

Research output: Contribution to journalLiterature reviewpeer-review


Chronic obstructive pulmonary disease (COPD) is one of the leading causes of morbidity and mortality worldwide COPD is defined by irreversible airflow obstruction It is a heterogeneous disease affecting the airways and/or the parenchyma with different severity during the course of the disease These different aspects of COPD can be addressed by imaging using a combination of morphological and functional techniques Computed tomography (CT) is the technique of choice for morphological imaging of the lung parenchyma and airways This morphological Information is to be accomplished by functional information about ventilation and perfusion mainly provided by magnetic resonance imaging (MRI) The comprehensive diagnostic possibilities of CT complemented by MRI will allow for a more sensitive detection phenotype-driven characterization, and dedicated therapy monitoring of the disease

Original languageEnglish
Pages (from-to)1340-1352
Number of pages13
JournalJournal of Magnetic Resonance Imaging
Issue number6
Publication statusPublished - Dec 2010


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