Immunity to a parasite that transforms T lymphocytes

Declan McKeever, Ivan Morrison

Research output: Contribution to journalLiterature reviewpeer-review


The past year has seen the first direct evidence that parasite-specific CD8+ T cells can protect cattle against patent infection with Theileria parva. These studies were based on the adoptive transfer between monozygous twins of lymphocytes responding to a challenge with the parasite. Immunization trials are also continuing with a candidate neutralizing vaccine based on the dominant antigen of the T. parva sporozoite surface. This progress has considerably enhanced the prospects for an improved vaccine against the parasite.
Original languageEnglish
Pages (from-to)564-7
Number of pages4
JournalCurrent Opinion in Immunology
Issue number4
Publication statusPublished - Aug 1994


  • Animals
  • Cattle
  • Immunity
  • Lymphocyte Activation
  • Protozoan Vaccines/immunology
  • T-Lymphocytes/immunology
  • Theileria parva/immunology
  • Theileriasis/immunology


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