Immunity to a parasite that transforms T lymphocytes

Declan McKeever, Ivan Morrison

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

The past year has seen the first direct evidence that parasite-specific CD8+ T cells can protect cattle against patent infection with Theileria parva. These studies were based on the adoptive transfer between monozygous twins of lymphocytes responding to a challenge with the parasite. Immunization trials are also continuing with a candidate neutralizing vaccine based on the dominant antigen of the T. parva sporozoite surface. This progress has considerably enhanced the prospects for an improved vaccine against the parasite.
Original languageEnglish
Pages (from-to)564-7
Number of pages4
JournalCurrent Opinion in Immunology
Volume6
Issue number4
DOIs
Publication statusPublished - Aug 1994

Keywords

  • Animals
  • Cattle
  • Immunity
  • Lymphocyte Activation
  • Protozoan Vaccines/immunology
  • T-Lymphocytes/immunology
  • Theileria parva/immunology
  • Theileriasis/immunology

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