Immunity to a parasite that transforms T lymphocytes

Declan McKeever; Ivan Morrison

doi:10.1016/0952-7915(94)90142-2

Immunity to a parasite that transforms T lymphocytes

Declan McKeever, Ivan Morrison

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Literature review › peer-review

Abstract / Description of output

The past year has seen the first direct evidence that parasite-specific CD8+ T cells can protect cattle against patent infection with Theileria parva. These studies were based on the adoptive transfer between monozygous twins of lymphocytes responding to a challenge with the parasite. Immunization trials are also continuing with a candidate neutralizing vaccine based on the dominant antigen of the T. parva sporozoite surface. This progress has considerably enhanced the prospects for an improved vaccine against the parasite.

Original language	English
Pages (from-to)	564-7
Number of pages	4
Journal	Current Opinion in Immunology
Volume	6
Issue number	4
DOIs	https://doi.org/10.1016/0952-7915(94)90142-2
Publication status	Published - Aug 1994

Keywords / Materials (for Non-textual outputs)

Animals
Cattle
Immunity
Lymphocyte Activation
Protozoan Vaccines/immunology
T-Lymphocytes/immunology
Theileria parva/immunology
Theileriasis/immunology

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10.1016/0952-7915(94)90142-2

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@article{b6fd7ca9e1564bc3bcd2a76d9ed48b7d,

title = "Immunity to a parasite that transforms T lymphocytes",

abstract = "The past year has seen the first direct evidence that parasite-specific CD8+ T cells can protect cattle against patent infection with Theileria parva. These studies were based on the adoptive transfer between monozygous twins of lymphocytes responding to a challenge with the parasite. Immunization trials are also continuing with a candidate neutralizing vaccine based on the dominant antigen of the T. parva sporozoite surface. This progress has considerably enhanced the prospects for an improved vaccine against the parasite.",

keywords = "Animals, Cattle, Immunity, Lymphocyte Activation, Protozoan Vaccines/immunology, T-Lymphocytes/immunology, Theileria parva/immunology, Theileriasis/immunology",

author = "Declan McKeever and Ivan Morrison",

year = "1994",

month = aug,

doi = "10.1016/0952-7915(94)90142-2",

language = "English",

volume = "6",

pages = "564--7",

journal = "Current Opinion in Immunology",

issn = "0952-7915",

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TY - JOUR

T1 - Immunity to a parasite that transforms T lymphocytes

AU - McKeever, Declan

AU - Morrison, Ivan

PY - 1994/8

Y1 - 1994/8

N2 - The past year has seen the first direct evidence that parasite-specific CD8+ T cells can protect cattle against patent infection with Theileria parva. These studies were based on the adoptive transfer between monozygous twins of lymphocytes responding to a challenge with the parasite. Immunization trials are also continuing with a candidate neutralizing vaccine based on the dominant antigen of the T. parva sporozoite surface. This progress has considerably enhanced the prospects for an improved vaccine against the parasite.

AB - The past year has seen the first direct evidence that parasite-specific CD8+ T cells can protect cattle against patent infection with Theileria parva. These studies were based on the adoptive transfer between monozygous twins of lymphocytes responding to a challenge with the parasite. Immunization trials are also continuing with a candidate neutralizing vaccine based on the dominant antigen of the T. parva sporozoite surface. This progress has considerably enhanced the prospects for an improved vaccine against the parasite.

KW - Animals

KW - Cattle

KW - Immunity

KW - Lymphocyte Activation

KW - Protozoan Vaccines/immunology

KW - T-Lymphocytes/immunology

KW - Theileria parva/immunology

KW - Theileriasis/immunology

U2 - 10.1016/0952-7915(94)90142-2

DO - 10.1016/0952-7915(94)90142-2

M3 - Literature review

SN - 0952-7915

VL - 6

SP - 564

EP - 567

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

IS - 4

ER -

Immunity to a parasite that transforms T lymphocytes

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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