Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours

T H M Vargas; L H Pulz; C N Barra; S R Kleeb; J G Xavier; J L Catão-Dias; H Fukumasu; A T Nishiya; R F Strefezzi

doi:10.1016/j.jcpa.2015.08.010

Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours

T H M Vargas, L H Pulz, C N Barra, S R Kleeb, J G Xavier, J L Catão-Dias, H Fukumasu, A T Nishiya, R F Strefezzi

Royal (Dick) School of Veterinary Studies

Research output: Contribution to journal › Article › peer-review

Abstract

Cancer stem cells (CSCs) are related to malignancy and resistance to chemotherapy in several tumours. OCT4 is a 'pluripotency factor' that is expressed by these cells. The aim of the present study was to investigate OCT4 expression in canine cutaneous mast cell tumours (MCTs) by means of immunohistochemistry. Twenty-eight cases were evaluated and showed variable immunolabelling patterns. The dogs were treated by surgery alone and followed up for a minimum of 180 days. No significant difference was found between histopathological grades and similar results were obtained for mortality due to the disease and post-surgical survival. These preliminary results suggest that OCT4 expression is not a precise prognostic indicator for canine MCT.

Original language	English
Pages (from-to)	251-5
Number of pages	5
Journal	Journal of Comparative Pathology
Volume	153
Issue number	4
DOIs	https://doi.org/10.1016/j.jcpa.2015.08.010
Publication status	Published - Nov 2015

Keywords / Materials (for Non-textual outputs)

Animals
Biomarkers, Tumor/analysis
Dog Diseases/metabolism
Dogs
Immunohistochemistry
Mastocytosis, Cutaneous/metabolism
Octamer Transcription Factor-3/analysis

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10.1016/j.jcpa.2015.08.010

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title = "Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours",

abstract = "Cancer stem cells (CSCs) are related to malignancy and resistance to chemotherapy in several tumours. OCT4 is a 'pluripotency factor' that is expressed by these cells. The aim of the present study was to investigate OCT4 expression in canine cutaneous mast cell tumours (MCTs) by means of immunohistochemistry. Twenty-eight cases were evaluated and showed variable immunolabelling patterns. The dogs were treated by surgery alone and followed up for a minimum of 180 days. No significant difference was found between histopathological grades and similar results were obtained for mortality due to the disease and post-surgical survival. These preliminary results suggest that OCT4 expression is not a precise prognostic indicator for canine MCT. ",

keywords = "Animals, Biomarkers, Tumor/analysis, Dog Diseases/metabolism, Dogs, Immunohistochemistry, Mastocytosis, Cutaneous/metabolism, Octamer Transcription Factor-3/analysis",

author = "Vargas, {T H M} and Pulz, {L H} and Barra, {C N} and Kleeb, {S R} and Xavier, {J G} and Cat{\~a}o-Dias, {J L} and H Fukumasu and Nishiya, {A T} and Strefezzi, {R F}",

year = "2015",

month = nov,

doi = "10.1016/j.jcpa.2015.08.010",

language = "English",

volume = "153",

pages = "251--5",

journal = "Journal of Comparative Pathology",

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TY - JOUR

T1 - Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours

AU - Vargas, T H M

AU - Pulz, L H

AU - Barra, C N

AU - Kleeb, S R

AU - Xavier, J G

AU - Catão-Dias, J L

AU - Fukumasu, H

AU - Nishiya, A T

AU - Strefezzi, R F

PY - 2015/11

Y1 - 2015/11

N2 - Cancer stem cells (CSCs) are related to malignancy and resistance to chemotherapy in several tumours. OCT4 is a 'pluripotency factor' that is expressed by these cells. The aim of the present study was to investigate OCT4 expression in canine cutaneous mast cell tumours (MCTs) by means of immunohistochemistry. Twenty-eight cases were evaluated and showed variable immunolabelling patterns. The dogs were treated by surgery alone and followed up for a minimum of 180 days. No significant difference was found between histopathological grades and similar results were obtained for mortality due to the disease and post-surgical survival. These preliminary results suggest that OCT4 expression is not a precise prognostic indicator for canine MCT.

AB - Cancer stem cells (CSCs) are related to malignancy and resistance to chemotherapy in several tumours. OCT4 is a 'pluripotency factor' that is expressed by these cells. The aim of the present study was to investigate OCT4 expression in canine cutaneous mast cell tumours (MCTs) by means of immunohistochemistry. Twenty-eight cases were evaluated and showed variable immunolabelling patterns. The dogs were treated by surgery alone and followed up for a minimum of 180 days. No significant difference was found between histopathological grades and similar results were obtained for mortality due to the disease and post-surgical survival. These preliminary results suggest that OCT4 expression is not a precise prognostic indicator for canine MCT.

KW - Animals

KW - Biomarkers, Tumor/analysis

KW - Dog Diseases/metabolism

KW - Dogs

KW - Immunohistochemistry

KW - Mastocytosis, Cutaneous/metabolism

KW - Octamer Transcription Factor-3/analysis

U2 - 10.1016/j.jcpa.2015.08.010

DO - 10.1016/j.jcpa.2015.08.010

M3 - Article

C2 - 26460092

SN - 0021-9975

VL - 153

SP - 251

EP - 255

JO - Journal of Comparative Pathology

JF - Journal of Comparative Pathology

IS - 4

ER -

Immunohistochemical Expression of the Pluripotency Factor OCT4 in Canine Mast Cell Tumours

Abstract

Keywords / Materials (for Non-textual outputs)

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