Immunohistochemistry for small cell carcinoma a potential diagnostic pitfall

William Wallace, David Dorward, Donald Salter

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The morphological appearances of small cell lung carcinoma (SCLC) are often characteristic however immunohistochemistry (IHC) is frequently employed to support the diagnosis, especially when there is crush artefact (1). In general histopathologists look for expression of cytokeratins, CD56 and TTF1 but it is well recognised that SCLC may not show typical staining reactions. While CD56 is usually expressed TTF1 may be negative and cytokeratin staining may be very focal or even absent (1,2). We report three cases of mediastinal alveolar rhabdomyosarcoma who presented with radiological features of lung cancer where the morphological and immunohistochemical profile mimicked SCLC.
Original languageEnglish
JournalHistopathology
Early online date15 Nov 2018
DOIs
Publication statusE-pub ahead of print - 15 Nov 2018

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