Abstract / Description of output
OPD4 is a recently described monoclonal antibody that recognizes a fixation-resistant 200 kD antigen restricted to a subset of T cells. Immunolabelling with OPD4 in paraffin sections of normal lymphoid tissues and cases of malignant lymphoma was compared with that of other antibodies in common use, including the T-cell restricted antibodies MT1 and UCHL1 and the B-cell restricted antibodies MB1, F8-11-13, and L26. OPD4 showed similar immunoreactivity to UCHL1 in normal tissues. OPD4 did not stain Reed-Sternberg cells in Hodgkin's disease. In non-Hodgkin's lymphomas, OPD4, like UCHL1, reacted with only 2/22 B-cell lymphomas. OPD4 was, however, less useful as a marker of T-cell lymphomas, staining only 11/32 cases, while UCHL1 stained 22/32 cases. We conclude that OPD4 is not a useful antibody for the routine diagnosis of T-cell lymphoma.
Original language | English |
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Pages (from-to) | 119-25 |
Number of pages | 7 |
Journal | The Journal of Pathology |
Volume | 164 |
Issue number | 2 |
DOIs | |
Publication status | Published - Jun 1991 |
Keywords / Materials (for Non-textual outputs)
- Adult
- Antibodies, Monoclonal
- Child
- Hodgkin Disease
- Humans
- Immunoenzyme Techniques
- Lymph Nodes
- Lymphoid Tissue
- Lymphoma
- Lymphoma, B-Cell
- Lymphoma, T-Cell
- Spleen
- Thymus Gland