Immunopathology of Chlamydophila abortus infection in sheep and mice

K Kerr, Gary Entrican, Declan McKeever, D. Longbottom

Research output: Contribution to journalLiterature reviewpeer-review

Abstract

Chlamydophila abortus targets the placenta, causing tissue damage, inflammation and abortion (enzootic abortion of ewes). It is one of the main infectious causes of abortion in ewes, resulting in major economic losses to agricultural industries worldwide. Although ruminants and pigs are the principal hosts, humans are also susceptible to infection. Control of disease requires a host inflammatory response, which is likely to contribute to pathology and abortion. Mouse models have been widely used to provide insight into the role of specific immune cells in controlling infection and disease. The use of such model systems for investigating the mechanisms of abortion, latency, persistence, and immunity to reinfection will result in the identification of novel vaccine control strategies for sheep.
Original languageEnglish
Pages (from-to)1-7
Number of pages7
JournalResearch in Veterinary Science
Volume78
Issue number1
DOIs
Publication statusPublished - Feb 2005

Keywords

  • Chlamydophila abortus
  • Enzootic abortion of ewes
  • Pregnant mouse model
  • Proinflammatory cytokines
  • Pregnancy hormones

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