Abstract / Description of output
Ischemic and hemorrhagic strokes have different etiologies, but share some pathogenic mechanisms, including a pro-neurotoxic effect of endogenous tissue plasminogen activator (tPA) via N-methyl-d-Aspartate (NMDA) receptors. Thus, in a model of intracerebral hemorrhage in rats, we investigated the therapeutic value of a strategy of immunotherapy (αATD-GluN1 antibody) preventing the interaction of tPA with NMDA receptors. We found that a single intravenous injection of αATD-GluN1 reduced brain edema, neuronal death, microglial activation and functional deficits following intracerebral hemorrhage, without affecting the hematoma volume.
Original language | English |
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Pages (from-to) | 267-71 |
Number of pages | 5 |
Journal | Neuropharmacology |
Volume | 67 |
DOIs | |
Publication status | Published - Apr 2013 |
Keywords / Materials (for Non-textual outputs)
- Animals
- Antibodies, Monoclonal, Murine-Derived/administration & dosage
- Immunotherapy/methods
- Intracranial Hemorrhages/immunology
- Male
- Mice
- Random Allocation
- Rats
- Rats, Sprague-Dawley
- Receptors, N-Methyl-D-Aspartate/metabolism
- Stroke/immunology
- Tissue Plasminogen Activator/antagonists & inhibitors
- Treatment Outcome