TY - JOUR
T1 - IMOP
T2 - randomised placebo controlled trial of outpatient cervical ripening with isosorbide mononitrate (IMN) prior to induction of labour - clinical trial with analyses of efficacy, cost effectiveness and acceptability
AU - Bollapragada, Shrikant
AU - Mackenzie, Fiona
AU - Norrie, John
AU - Petrou, Stavros
AU - Reid, Margaret
AU - Greer, Ian
AU - Osman, Inass
AU - Norman, Jane E
PY - 2006
Y1 - 2006
N2 - There is increasing interest in carrying out pre-induction cervical ripening on an outpatient basis. However, there are concerns about the use of prostaglandins, the agents commonly used in hospital settings for this indication, because prostaglandins induce uterine contractions that may lead to fetal hypoxia. Indeed, in a recent study we demonstrated abnormalities in 9% of fetal heart rate tracings performed following prostaglandin induced cervical ripening at term. In contrast, we confirmed in the same study that isosorbide mononitrate (IMN) (administered on an inpatient basis) was both effective in inducing cervical ripening at term, and was associated with no associated fetal heart rate abnormalities.
AB - There is increasing interest in carrying out pre-induction cervical ripening on an outpatient basis. However, there are concerns about the use of prostaglandins, the agents commonly used in hospital settings for this indication, because prostaglandins induce uterine contractions that may lead to fetal hypoxia. Indeed, in a recent study we demonstrated abnormalities in 9% of fetal heart rate tracings performed following prostaglandin induced cervical ripening at term. In contrast, we confirmed in the same study that isosorbide mononitrate (IMN) (administered on an inpatient basis) was both effective in inducing cervical ripening at term, and was associated with no associated fetal heart rate abnormalities.
U2 - 10.1186/1471-2393-6-25
DO - 10.1186/1471-2393-6-25
M3 - Article
C2 - 16869966
SN - 1471-2393
VL - 6
SP - 25
JO - BMC pregnancy and childbirth
JF - BMC pregnancy and childbirth
ER -