Impact of adrenalectomy on 5-HT6 and 5-HT7 receptor gene expression in the rat hippocampus

J L W Yau, J Noble, J Widdowson, J R Seckl

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Both glucocorticoid excess and decreased serotonergic (5-HT) transmission may cause depression. The recently cloned 5-HT6 and 5-HT7 receptors have high affinity for antidepressants. Here, we show that pharmacological adrenalectomy increases 5-HT6 and 5-HT7 receptor mRNA expression in specific hippocampal subfields, effects partly reversed by corticosterone replacement. Increased 5-HT6 and 5-HT7 receptor expression may provide a basis, in part, for the therapeutic actions of adrenal steroid synthesis inhibitors in resistant depression. (C) 1997 Elsevier Science B.V. All rights reserved.

Original languageEnglish
Pages (from-to)182-186
Number of pages5
JournalMolecular brain research
Volume45
Issue number1
Publication statusPublished - Apr 1997

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