Abstract
Both glucocorticoid excess and decreased serotonergic (5-HT) transmission may cause depression. The recently cloned 5-HT6 and 5-HT7 receptors have high affinity for antidepressants. Here, we show that pharmacological adrenalectomy increases 5-HT6 and 5-HT7 receptor mRNA expression in specific hippocampal subfields, effects partly reversed by corticosterone replacement. Increased 5-HT6 and 5-HT7 receptor expression may provide a basis, in part, for the therapeutic actions of adrenal steroid synthesis inhibitors in resistant depression. (C) 1997 Elsevier Science B.V. All rights reserved.
Original language | English |
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Pages (from-to) | 182-186 |
Number of pages | 5 |
Journal | Molecular brain research |
Volume | 45 |
Issue number | 1 |
Publication status | Published - Apr 1997 |