Impact of blood rheology on wall shear stress in a model of the middle cerebral artery

Miguel O Bernabeu, Rupert W Nash, Derek Groen, Hywel B Carver, James Hetherington, Timm Krueger, Peter V Coveney

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Perturbations to the homeostatic distribution of mechanical forces exerted by blood on the endothelial layer have been correlated with vascular pathologies, including intracranial aneurysms and atherosclerosis. Recent computational work suggests that, in order to correctly characterize such forces, the shear-thinning properties of blood must be taken into account. To the best of our knowledge, these findings have never been comparedagainst experimentally observed pathological thresholds. In thiswork, we apply the three-band diagram (TBD) analysis due to Gizzi et al. (Gizzi et al. 2011 Three-band decomposition analysis of wall shear stress in pulsatile flows. Phys. Rev. E 83, 031902. (doi: 10.1103/PhysRevE.83.031902)) to assess the impact of the choice of blood rheology model on acomputational model of the right middle cerebral artery. Our results showthat, in themodel under study, the differences between thewall shear stress predicted by a Newtonian model and thewell-known Carreau-Yasuda generalized Newtonian model are only significant if the vascular pathology under study is associated with a pathological threshold in the range 0.94-1.56 Pa, where the results of the TBD analysis of the rheology models considered differs. Otherwise, we observe no significant differences.

Original languageEnglish
Article number20120094
Number of pages7
JournalInterface Focus
Issue number2
Publication statusPublished - 6 Apr 2013

Keywords / Materials (for Non-textual outputs)

  • blood flow modelling
  • rheology
  • multi-scale modelling
  • lattice Boltzmann
  • three-band diagram analysis
  • RISK


Dive into the research topics of 'Impact of blood rheology on wall shear stress in a model of the middle cerebral artery'. Together they form a unique fingerprint.

Cite this