Impact of HDL on adipose tissue metabolism and adiponectin expression

Sophie Van Linthout; Anna Foryst-Ludwig; Frank Spillmann; Jun Peng; Yingmei Feng; Marco Meloni; Eline Van Craeyveld; Ulrich Kintscher; Heinz Peter Schultheiss; Bart De Geest; Carsten Tschöpe

doi:10.1016/j.atherosclerosis.2010.01.001

Impact of HDL on adipose tissue metabolism and adiponectin expression

Sophie Van Linthout, Anna Foryst-Ludwig, Frank Spillmann, Jun Peng, Yingmei Feng, Marco Meloni, Eline Van Craeyveld, Ulrich Kintscher, Heinz Peter Schultheiss, Bart De Geest, Carsten Tschöpe^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Objective: The objective of the current study was to investigate the hypothesis that high-density lipoprotein (HDL) influences adipocyte metabolism and adiponectin expression. Therefore, HDL was increased in vivo via apolipoprotein (apo) A-I gene transfer and in vitro via supplementation of HDL to partly differentiated adipocytes, in the presence or absence of lipopolysaccharide (LPS), known to decrease HDL cholesterol and adiponectin levels in vivo. Methods and results: Apo A-I transfer resulted in a significant increase of HDL cholesterol in control and LPS-injected C57BL/6 mice, which was paralleled by an increase in plasma adiponectin levels and adiponectin expression in abdominal fat. Triglyceride and free fatty acids levels after LPS administration were 2.2-fold (p

Original language	English
Pages (from-to)	438-444
Number of pages	7
Journal	Atherosclerosis
Volume	210
Issue number	2
DOIs	https://doi.org/10.1016/j.atherosclerosis.2010.01.001
Publication status	Published - Jun 2010

Keywords / Materials (for Non-textual outputs)

Adiponectin
Apo A-I
HDL cholesterol

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10.1016/j.atherosclerosis.2010.01.001

Cite this

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title = "Impact of HDL on adipose tissue metabolism and adiponectin expression",

abstract = "Objective: The objective of the current study was to investigate the hypothesis that high-density lipoprotein (HDL) influences adipocyte metabolism and adiponectin expression. Therefore, HDL was increased in vivo via apolipoprotein (apo) A-I gene transfer and in vitro via supplementation of HDL to partly differentiated adipocytes, in the presence or absence of lipopolysaccharide (LPS), known to decrease HDL cholesterol and adiponectin levels in vivo. Methods and results: Apo A-I transfer resulted in a significant increase of HDL cholesterol in control and LPS-injected C57BL/6 mice, which was paralleled by an increase in plasma adiponectin levels and adiponectin expression in abdominal fat. Triglyceride and free fatty acids levels after LPS administration were 2.2-fold (p",

keywords = "Adiponectin, Apo A-I, HDL cholesterol",

author = "{Van Linthout}, Sophie and Anna Foryst-Ludwig and Frank Spillmann and Jun Peng and Yingmei Feng and Marco Meloni and {Van Craeyveld}, Eline and Ulrich Kintscher and Schultheiss, {Heinz Peter} and {De Geest}, Bart and Carsten Tsch{\"o}pe",

year = "2010",

month = jun,

doi = "10.1016/j.atherosclerosis.2010.01.001",

language = "English",

volume = "210",

pages = "438--444",

journal = "Atherosclerosis",

issn = "0021-9150",

publisher = "Elsevier Ireland Ltd",

number = "2",

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T1 - Impact of HDL on adipose tissue metabolism and adiponectin expression

AU - Van Linthout, Sophie

AU - Foryst-Ludwig, Anna

AU - Spillmann, Frank

AU - Peng, Jun

AU - Feng, Yingmei

AU - Meloni, Marco

AU - Van Craeyveld, Eline

AU - Kintscher, Ulrich

AU - Schultheiss, Heinz Peter

AU - De Geest, Bart

AU - Tschöpe, Carsten

PY - 2010/6

Y1 - 2010/6

N2 - Objective: The objective of the current study was to investigate the hypothesis that high-density lipoprotein (HDL) influences adipocyte metabolism and adiponectin expression. Therefore, HDL was increased in vivo via apolipoprotein (apo) A-I gene transfer and in vitro via supplementation of HDL to partly differentiated adipocytes, in the presence or absence of lipopolysaccharide (LPS), known to decrease HDL cholesterol and adiponectin levels in vivo. Methods and results: Apo A-I transfer resulted in a significant increase of HDL cholesterol in control and LPS-injected C57BL/6 mice, which was paralleled by an increase in plasma adiponectin levels and adiponectin expression in abdominal fat. Triglyceride and free fatty acids levels after LPS administration were 2.2-fold (p

AB - Objective: The objective of the current study was to investigate the hypothesis that high-density lipoprotein (HDL) influences adipocyte metabolism and adiponectin expression. Therefore, HDL was increased in vivo via apolipoprotein (apo) A-I gene transfer and in vitro via supplementation of HDL to partly differentiated adipocytes, in the presence or absence of lipopolysaccharide (LPS), known to decrease HDL cholesterol and adiponectin levels in vivo. Methods and results: Apo A-I transfer resulted in a significant increase of HDL cholesterol in control and LPS-injected C57BL/6 mice, which was paralleled by an increase in plasma adiponectin levels and adiponectin expression in abdominal fat. Triglyceride and free fatty acids levels after LPS administration were 2.2-fold (p

KW - Adiponectin

KW - Apo A-I

KW - HDL cholesterol

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U2 - 10.1016/j.atherosclerosis.2010.01.001

DO - 10.1016/j.atherosclerosis.2010.01.001

M3 - Article

C2 - 20202635

AN - SCOPUS:77952474019

SN - 0021-9150

VL - 210

SP - 438

EP - 444

JO - Atherosclerosis

JF - Atherosclerosis

IS - 2

ER -

Impact of HDL on adipose tissue metabolism and adiponectin expression

Abstract

Keywords / Materials (for Non-textual outputs)

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