Impact of HDL on adipose tissue metabolism and adiponectin expression

Sophie Van Linthout, Anna Foryst-Ludwig, Frank Spillmann, Jun Peng, Yingmei Feng, Marco Meloni, Eline Van Craeyveld, Ulrich Kintscher, Heinz Peter Schultheiss, Bart De Geest, Carsten Tschöpe*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Objective: The objective of the current study was to investigate the hypothesis that high-density lipoprotein (HDL) influences adipocyte metabolism and adiponectin expression. Therefore, HDL was increased in vivo via apolipoprotein (apo) A-I gene transfer and in vitro via supplementation of HDL to partly differentiated adipocytes, in the presence or absence of lipopolysaccharide (LPS), known to decrease HDL cholesterol and adiponectin levels in vivo. Methods and results: Apo A-I transfer resulted in a significant increase of HDL cholesterol in control and LPS-injected C57BL/6 mice, which was paralleled by an increase in plasma adiponectin levels and adiponectin expression in abdominal fat. Triglyceride and free fatty acids levels after LPS administration were 2.2-fold (p

Original languageEnglish
Pages (from-to)438-444
Number of pages7
JournalAtherosclerosis
Volume210
Issue number2
DOIs
Publication statusPublished - Jun 2010

Keywords / Materials (for Non-textual outputs)

  • Adiponectin
  • Apo A-I
  • HDL cholesterol

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