Impact of mannose-binding lectin insufficiency on the course of cystic fibrosis: A review and meta-analysis

James D Chalmers, Gillian B Fleming, Adam T Hill, David C Kilpatrick

Research output: Contribution to journalArticlepeer-review

Abstract

Mannose-binding lectin (MBL) is an innate immune protein produced by the liver. MBL binds to glycoconjugates containing mannose, fucose or N-acetylglucosamine that are present in a wide variety of bacteria, viruses and fungi. Upon binding, MBL may active the lectin pathway of complement or directly opsonize organisms to enhance phagocytosis. MBL is primarily a serum protein but accumulates in the lung during acute inflammation. Recent evidence suggests an important role for MBL in a variety of infectious disorders. Cystic fibrosis (CF) is a multisystem disease caused by mutations in the gene encoding the CF transmembrane regulator (CFTR). The course of CF lung disease is highly variable even in patients with the same CFTR genotype, suggesting that other modulator genes are important for prognosis. MBL has been proposed as a possible modulator of clinical severity in CF. In this review and meta-analysis, we found that MBL2 genotypes associated with MBL insufficiency were associated with earlier acquisition of Pseudomonas aeruginosa (P 
Original languageEnglish
Pages (from-to)271-82
Number of pages12
JournalGlycobiology
Volume21
Issue number3
DOIs
Publication statusPublished - 2011

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