Impact of patient selection on performance of an early rule-out pathway for myocardial infarction: from research to the real world

Anda Bularga; Kuan Ken Lee; Shah Anoop S V; Atul Anand; Andrew R Chapman; Chris Tuck; David E Newby; Sarah  Jenks; Nicholas L Mills; Dorien Kimenai

doi:10.1161/CIRCULATIONAHA.122.062419

Impact of patient selection on performance of an early rule-out pathway for myocardial infarction: from research to the real world

Anda Bularga, Kuan Ken Lee, Shah Anoop S V, Atul Anand, Andrew R Chapman, Chris Tuck, David E Newby, Sarah Jenks, Nicholas L Mills, Dorien Kimenai^*

^*Corresponding author for this work

Research output: Contribution to journal › Letter › peer-review

Original language	English
Journal	Circulation
DOIs	https://doi.org/10.1161/CIRCULATIONAHA.122.062419
Publication status	Published - 31 Jan 2023

Keywords / Materials (for Non-textual outputs)

Myocardial Infarction
acute coronary syndrome
cardiac troponin

Access to Document

10.1161/CIRCULATIONAHA.122.062419

Research letter CIRCULATIONAHA 2022 062419R1Accepted author manuscript, 1.07 MBLicence: Creative Commons: Attribution (CC-BY)

Machine learning and the diagnosis of myocardial infarction
Newby, D. (Principal Investigator) & Mills, N. (Co-investigator)
MRC
1/02/21 → 31/01/23
Project: Research
High-Sensitivity Cardiac Troponin Beyond the Acute Coronary Syndrome
Mills, N. (Principal Investigator), Anand, A. (Co-investigator), Chapman, A. (Co-investigator), Ferry, A. (Co-investigator), Newby, D. (Co-investigator), Strachan, F. (Co-investigator) & Tsanas, T. (Co-investigator)
UK-based charities
1/06/20 → 31/05/25
Project: Research
Research Excellence Award Number 3
Newby, D. (Principal Investigator), Bailey, M. (Co-investigator), Baker, A. (Co-investigator), Dweck, M. (Co-investigator), Mills, N. (Co-investigator), Morton, N. (Co-investigator), Pearson, E. (Co-investigator), Reynolds, R. (Co-investigator), Semple, R. (Co-investigator) & Webster, S. (Co-investigator)
UK-based charities
1/04/19 → 31/03/24
Project: Research

Cite this

@article{7693b8d8e2394172b5fa35ed7c83b0fd,

title = "Impact of patient selection on performance of an early rule-out pathway for myocardial infarction: from research to the real world",

keywords = "Myocardial Infarction, acute coronary syndrome, cardiac troponin",

author = "Anda Bularga and Lee, {Kuan Ken} and {Anoop S V}, Shah and Atul Anand and Chapman, {Andrew R} and Chris Tuck and Newby, {David E} and Sarah Jenks and Mills, {Nicholas L} and Dorien Kimenai",

note = "Funding Information: The British Heart Foundation (SP/12/10/29922) funded the High-STEACS trial with support from a Research Excellence Award (RE/18/5/34216). Dr Bularga is supported by a Clinical Research Training Fellowship (MR/V007254/1) from the Medical Research Council. Dr Mills is supported by a Chair Award (CH/F/21/90010), a Programme Grant (RG/20/10/34966), and a Research Excellence Award (RE/18/5/34216) from the British Heart Foundation. Dr Kimenai is supported by a grant from Health Data Research UK, which receives its funding from HDR UK Ltd (HDR-5012) funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation and the Wellcome Trust. Abbott Laboratories provided cardiac troponin assay reagents, calibrators, and controls without charge. Funding Information: Dr Shah{\textquoteright}s institution has received honoraria from Abbott Diagnostics. Dr Mills reports research grants awarded to the University of Edinburgh from Abbott Diagnostics and Siemens Healthineers outside the submitted work, and honoraria from Abbott Diagnostics, Siemens Healthineers, Roche Diagnostics and LumiraDx. All other authors have no interest to declare.",

year = "2023",

month = jan,

day = "31",

doi = "10.1161/CIRCULATIONAHA.122.062419",

language = "English",

journal = "Circulation",

issn = "0009-7322",

publisher = "Lippincott Williams and Wilkins",

}

TY - JOUR

T1 - Impact of patient selection on performance of an early rule-out pathway for myocardial infarction: from research to the real world

AU - Bularga, Anda

AU - Lee, Kuan Ken

AU - Anoop S V, Shah

AU - Anand, Atul

AU - Chapman, Andrew R

AU - Tuck, Chris

AU - Newby, David E

AU - Jenks, Sarah

AU - Mills, Nicholas L

AU - Kimenai, Dorien

N1 - Funding Information: The British Heart Foundation (SP/12/10/29922) funded the High-STEACS trial with support from a Research Excellence Award (RE/18/5/34216). Dr Bularga is supported by a Clinical Research Training Fellowship (MR/V007254/1) from the Medical Research Council. Dr Mills is supported by a Chair Award (CH/F/21/90010), a Programme Grant (RG/20/10/34966), and a Research Excellence Award (RE/18/5/34216) from the British Heart Foundation. Dr Kimenai is supported by a grant from Health Data Research UK, which receives its funding from HDR UK Ltd (HDR-5012) funded by the UK Medical Research Council, Engineering and Physical Sciences Research Council, Economic and Social Research Council, Department of Health and Social Care (England), Chief Scientist Office of the Scottish Government Health and Social Care Directorates, Health and Social Care Research and Development Division (Welsh Government), Public Health Agency (Northern Ireland), British Heart Foundation and the Wellcome Trust. Abbott Laboratories provided cardiac troponin assay reagents, calibrators, and controls without charge. Funding Information: Dr Shah’s institution has received honoraria from Abbott Diagnostics. Dr Mills reports research grants awarded to the University of Edinburgh from Abbott Diagnostics and Siemens Healthineers outside the submitted work, and honoraria from Abbott Diagnostics, Siemens Healthineers, Roche Diagnostics and LumiraDx. All other authors have no interest to declare.

PY - 2023/1/31

Y1 - 2023/1/31

KW - Myocardial Infarction

KW - acute coronary syndrome

KW - cardiac troponin

U2 - 10.1161/CIRCULATIONAHA.122.062419

DO - 10.1161/CIRCULATIONAHA.122.062419

M3 - Letter

SN - 0009-7322

JO - Circulation

JF - Circulation

ER -

Impact of patient selection on performance of an early rule-out pathway for myocardial infarction: from research to the real world

Keywords / Materials (for Non-textual outputs)

Access to Document

Projects

Machine learning and the diagnosis of myocardial infarction

High-Sensitivity Cardiac Troponin Beyond the Acute Coronary Syndrome

Research Excellence Award Number 3

Cite this