Impact of taxane-based chemotherapeutics on male reproductive function

Charvi Kanodia; Michael P Rimmer; Kathleen Duffin; Rod T Mitchell

doi:10.1530/RAF-22-0134

Impact of taxane-based chemotherapeutics on male reproductive function

Charvi Kanodia, Michael P Rimmer, Kathleen Duffin, Rod T Mitchell

Research output: Contribution to journal › Article › peer-review

Abstract

Men and boys with cancer treated with chemotherapy are known to have reduced fertility following their treatment. This is because some chemotherapy drugs can damage the cells in the testicles that make sperm. This study found there is limited information available on the effect of one group of chemotherapy drugs, called taxanes, on testicular function and fertility. More studies are needed to aid clinicians in advising patients on how this taxane-based chemotherapy may affect their future fertility.

Original language	English
Article number	e220134
Journal	Reproduction & Fertility
Volume	4
Issue number	1
Early online date	1 Feb 2023
DOIs	https://doi.org/10.1530/RAF-22-0134
Publication status	Published - 2023

Keywords / Materials (for Non-textual outputs)

chemotherapy
fertility
fertility preservation
paclitaxel
taxanes

Access to Document

10.1530/RAF-22-0134

RAF-22-0134.R1_Proof_hiFeb23Accepted author manuscript, 326 KB

https://raf.bioscientifica.com/view/journals/raf/aop/raf-22-0134/raf-22-0134.xml

MRC Centre for Reproductive Health at the University of Edinburgh
Pollard, J.
MRC
12/09/16 → 11/09/22
Project: Research

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title = "Impact of taxane-based chemotherapeutics on male reproductive function",

abstract = "Men and boys with cancer treated with chemotherapy are known to have reduced fertility following their treatment. This is because some chemotherapy drugs can damage the cells in the testicles that make sperm. This study found there is limited information available on the effect of one group of chemotherapy drugs, called taxanes, on testicular function and fertility. More studies are needed to aid clinicians in advising patients on how this taxane-based chemotherapy may affect their future fertility.",

keywords = "chemotherapy, fertility, fertility preservation, paclitaxel, taxanes",

author = "Charvi Kanodia and Rimmer, {Michael P} and Kathleen Duffin and Mitchell, {Rod T}",

note = "Funding Information: MPR and RTM are funded by an MRC Centre for Reproductive Health Grant No: MR/N022556/1. RTM is funded by a UK Research and Innovation (UKRI) Future Leaders Fellowship MR/S017151/1. KD is funded by a CRUK grant (C157/A25193). Publisher Copyright: {\textcopyright} 2023 the author(s) Published by Bioscientifica Ltd.",

year = "2023",

doi = "10.1530/RAF-22-0134",

language = "English",

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T1 - Impact of taxane-based chemotherapeutics on male reproductive function

AU - Kanodia, Charvi

AU - Rimmer, Michael P

AU - Duffin, Kathleen

AU - Mitchell, Rod T

N1 - Funding Information: MPR and RTM are funded by an MRC Centre for Reproductive Health Grant No: MR/N022556/1. RTM is funded by a UK Research and Innovation (UKRI) Future Leaders Fellowship MR/S017151/1. KD is funded by a CRUK grant (C157/A25193). Publisher Copyright: © 2023 the author(s) Published by Bioscientifica Ltd.

PY - 2023

Y1 - 2023

N2 - Men and boys with cancer treated with chemotherapy are known to have reduced fertility following their treatment. This is because some chemotherapy drugs can damage the cells in the testicles that make sperm. This study found there is limited information available on the effect of one group of chemotherapy drugs, called taxanes, on testicular function and fertility. More studies are needed to aid clinicians in advising patients on how this taxane-based chemotherapy may affect their future fertility.

AB - Men and boys with cancer treated with chemotherapy are known to have reduced fertility following their treatment. This is because some chemotherapy drugs can damage the cells in the testicles that make sperm. This study found there is limited information available on the effect of one group of chemotherapy drugs, called taxanes, on testicular function and fertility. More studies are needed to aid clinicians in advising patients on how this taxane-based chemotherapy may affect their future fertility.

KW - chemotherapy

KW - fertility

KW - fertility preservation

KW - paclitaxel

KW - taxanes

U2 - 10.1530/RAF-22-0134

DO - 10.1530/RAF-22-0134

M3 - Article

C2 - 36795651

SN - 2633-8386

VL - 4

JO - Reproduction & Fertility

JF - Reproduction & Fertility

IS - 1

M1 - e220134

ER -

Impact of taxane-based chemotherapeutics on male reproductive function

Abstract

Keywords / Materials (for Non-textual outputs)

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Projects

MRC Centre for Reproductive Health at the University of Edinburgh

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