Impact of tissue plasminogen activator on the neurovascular unit: from clinical data to experimental evidence

Denis Vivien, Maxime Gauberti, Axel Montagne, Gilles Defer, Emmanuel Touzé

Research output: Contribution to journalReview articlepeer-review

Abstract

About 15 million strokes occur each year worldwide. As the number one cause of morbidity and acquired disability, stroke is a major drain on public health-care funding, due to long hospital stays followed by ongoing support in the community or nursing-home care. Although during the last 10 years we have witnessed a remarkable progress in the understanding of the pathophysiology of ischemic stroke, reperfusion induced by recombinant tissue-type plasminogen activator (tPA-Actilyse) remains the only approved acute treatment by the health authorities. The objective of the present review is to provide an overview of our present knowledge about the impact of tPA on the neurovascular unit during acute ischemic stroke.

Original languageEnglish
Pages (from-to)2119-34
Number of pages16
JournalJournal of Cerebral Blood Flow and Metabolism
Volume31
Issue number11
DOIs
Publication statusPublished - Nov 2011

Keywords

  • Acute Disease
  • Aging/pathology
  • Animals
  • Blood-Brain Barrier/drug effects
  • Brain/blood supply
  • Drug Administration Schedule
  • Fibrinolytic Agents/administration & dosage
  • Humans
  • Microvessels/drug effects
  • Stroke/drug therapy
  • Thrombolytic Therapy/methods
  • Tissue Plasminogen Activator/administration & dosage

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