Projects per year
Abstract / Description of output
Over the past two decades, advances in cancer therapy have significantly improved survival rates, particularly in childhood cancers. Still, many treatments pose a substantial risk for diminishing future fertility potential due to the gonadotoxic nature of many cancer regimens, justifying fertility preservation programs for both childhood and adult cancer patients. To assure a balance between offering fertility preservation and actual chance of infertility post-treatment, guidelines are in place. However, assessing the actual risk of infertility after treatment remains challenging, given the multi-faceted approach of many cancer treatment plans, which are continuously evolving. This review discusses the evolution of cancer therapy over the past 20 years and attempts to assess their impact on fertility after treatment. Overall, cancer regimens have shifted from broadly killing fast dividing cells to more targeting therapies, reducing collateral damage in general. Although progress has been made to reduce overall toxicity, unfortunately this does not automatically translate to reduced gonadotoxicity. Therefore, current fertility preservation programs continue to be an important part of cancer care.
Original language | English |
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Article number | 101308 |
Journal | Molecular Aspects of Medicine |
Volume | 100 |
Early online date | 11 Sept 2024 |
DOIs | |
Publication status | Published - 1 Dec 2024 |
Keywords / Materials (for Non-textual outputs)
- Cancer therapy
- Chemotherapy
- Radiation
- Gonadotoxicity
- Spermatogenesis
- Fertility preservation
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Dive into the research topics of 'Impacts of cancer therapy on male fertility: Past and present'. Together they form a unique fingerprint.Projects
- 2 Finished
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CRUK Centre - Clinical Training Award Cycle 3 2017 - Clinical PhD 1
1/04/17 → 31/03/21
Project: Research