Impaired spatial learning after saturation of long-term potentiation

Edvard I Moser, K A Krobert, M B Moser, R G Morris

Research output: Contribution to journalArticlepeer-review


If information is stored as activity-driven increases in synaptic weights in the hippocampal formation, saturation of hippocampal long-term potentiation (LTP) should impair learning. Here, rats in which one hippocampus had been lesioned were implanted with a multielectrode stimulating array across and into the angular bundle afferent to the other hippocampus. Repeated cross-bundle tetanization caused cumulative potentiation. Residual synaptic plasticity was assessed by tetanizing a naïve test electrode in the center of the bundle. Spatial learning was disrupted in animals with no residual LTP (<10 percent) but not in animals that were capable of further potentiation. Thus, saturation of hippocampal LTP impairs spatial learning.

Original languageEnglish
Pages (from-to)2038-42
Number of pages5
Issue number5385
Publication statusPublished - 25 Sep 1998


  • Animals
  • Dentate Gyrus
  • Electric Stimulation
  • Electrodes, Implanted
  • Evoked Potentials
  • Excitatory Postsynaptic Potentials
  • Hippocampus
  • Long-Term Potentiation
  • Male
  • Maze Learning
  • Perforant Pathway
  • Rats
  • Synapses
  • Tetany
  • Comment
  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.


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