Implications of Conflicting Associations of the Prion Protein (PrP) Gene with Scrapie Susceptibility and Fitness on the Persistence of Scrapie

A. Doeschl-Wilson, R. Sawalha, S. Gubbins, B. Villanueva

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

BACKGROUND: Existing mathematical models for scrapie dynamics in sheep populations assume that the PrP gene is only associated with scrapie susceptibility and with no other fitness related traits. This assumption contrasts recent findings of PrP gene associations with post-natal lamb survival in scrapie free Scottish Blackface populations. Lambs with scrapie resistant genotypes were found to have significantly lower survival rates than those with susceptible genotypes. The present study aimed to investigate how these conflicting PrP gene associations may affect the dynamic patterns of PrP haplotype frequencies and disease prevalence.

METHODOLOGY/PRINCIPAL FINDINGS: A deterministic mathematical model was developed to explore how the associations between PrP genotype and both scrapie susceptibility and postnatal lamb mortality affect the prevalence of scrapie and the associated change in PrP gene frequencies in a closed flock of sheep. The model incorporates empirical evidence on epidemiological and biological characteristics of scrapie and on mortality rates induced by causes other than scrapie. The model results indicate that unfavorable associations of the scrapie resistant PrP haplotypes with post-natal lamb mortality, if sufficiently strong, can increase scrapie prevalence during an epidemic, and result in scrapie persisting in the population. The range of model parameters, for which such effects were observed, is realistic but relatively narrow.

CONCLUSIONS/SIGNIFICANCE: The results of the present model suggest that for most parameter combinations an unfavourable association between PrP genotype and post-natal lamb mortality does not greatly alter the dynamics of scrapie and, hence, would not have an adverse impact on a breeding programme. There were, however, a range of scenarios, narrow, but realistic, in which such an unfavourable association resulted in an increased prevalence and in the persistence of infection. Consequently, associations between PrP genotypes and fitness traits should be taken into account when designing future models and breeding programmes.
Original languageEnglish
Article numbere7970
JournalPLoS ONE
Issue number11
Publication statusPublished - Nov 2009

Keywords / Materials (for Non-textual outputs)

  • Algorithms Animals Disease Susceptibility/epidemiology Gene Frequency Genetic Predisposition to Disease Genotype Haplotypes Models, Statistical Models, Theoretical Prions/ genetics/ physiology Scrapie/ genetics Sheep Stochastic Processes


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