Improving understanding and common usage of disease phenotypes, endotypes, biomarkers and precision therapies at the point of care

Dermot Ryan*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract / Description of output

Our understanding of asthma pathophysiology has moved from broncho-constriction to choric inflammation and now to phenotyping and endotyping. It is necessary to review this history to attempt to address the future understanding of the disease. Personalised care is an attempt to match each patient with the optimum intervention, guided by treatable traits and biomarkers. Currently, in primary care (point of care) there are limited biomarkers available with a greater range available in specialist care. Patient stratification is an element of personalised care which can be achieved in primary care, identifying those patients who remain uncontrolled in spite of structured assessment.

Original languageEnglish
Title of host publicationImplementing Precision Medicine in Best Practices of Chronic Airway Diseases
EditorsIoana Agache, Peter Hellings
PublisherElsevier
Pages189-193
Number of pages5
ISBN (Electronic)9780128134719
ISBN (Print)9780128134726
DOIs
Publication statusPublished - 1 Jan 2018

Keywords / Materials (for Non-textual outputs)

  • Asthma
  • Biomarkers
  • Clinical decision support system
  • Primary care
  • Steroid resistant asthma

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