TY - JOUR
T1 - In Semliki Forest virus encephalitis, antibody rapidly clears infectious virus and is required to eliminate viral material from the brain, but is not required to generate lesions of demyelination
AU - Fragkoudis, Rennos
AU - Ballany, Catherine M.
AU - Boyd, Amanda
AU - Fazakerley, John K.
PY - 2008/10
Y1 - 2008/10
N2 - Semliki Forest virus (SFV) infection of the laboratory mouse provides a well-characterized tractable system to study the pathogenesis of virus encephalitis and virus induced demyelination. In mu MT mice, which have no antibodies, infectious virus persisted in both the serum and the brain for several weeks, indicating that antibodies are required to eliminate infectious virus. In immunocompetent mice, virus infectivity in the brain was undetectable after the first week of infection, but virus RNA levels declined slowly. Following SFV infection, lesions of demyelination were present in the brains of both immunocompetent and mu MT mice, indicating that antibodies are not required to generate lesions of demyelination.
AB - Semliki Forest virus (SFV) infection of the laboratory mouse provides a well-characterized tractable system to study the pathogenesis of virus encephalitis and virus induced demyelination. In mu MT mice, which have no antibodies, infectious virus persisted in both the serum and the brain for several weeks, indicating that antibodies are required to eliminate infectious virus. In immunocompetent mice, virus infectivity in the brain was undetectable after the first week of infection, but virus RNA levels declined slowly. Following SFV infection, lesions of demyelination were present in the brains of both immunocompetent and mu MT mice, indicating that antibodies are not required to generate lesions of demyelination.
U2 - 10.1099/vir.0.2008/002238-0
DO - 10.1099/vir.0.2008/002238-0
M3 - Article
SN - 0022-1317
VL - 89
SP - 2565
EP - 2568
JO - Journal of General Virology
JF - Journal of General Virology
IS - 10
ER -