In Situ Nanoliter-Scale Polymer Fabrication for Flexible Cell Patterning

Albert R. Liberski, Rong Zhang, Mark Bradley

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Drug-testing technologies, biosensor fabrication, tissue engineering, and basic biological research depend strongly on the patterning of live animal cells. Current techniques for controlling cellular adhesion are restricted with two primary limitations. Firstly, the complexity of the available patterns is very limited and, secondly, the pallet of materials that induce cellular patterning is exhaustible. Here, we demonstrate a method for computer-aided control of cell patterning using a scientific inkjet printer that yields a highly complex cellular pattern suitable for applications in regenerative medicine and rapid prototyping, and a strategy for using in situ polymerization for fabrication polymeric patterns directly on-chip. (JALA 2009;14:285-93)

Original languageEnglish
Pages (from-to)285-293
Number of pages9
JournalJournal of The Association for Laboratory Automation
Volume14
Issue number5
DOIs
Publication statusPublished - Oct 2009

Keywords / Materials (for Non-textual outputs)

  • cell patterning
  • software for inkjet printing
  • mES cells
  • biomaterials
  • nL scale-in situ polymerization
  • synthetic cell binders
  • SELF-ASSEMBLED MONOLAYERS
  • DIP-PEN NANOLITHOGRAPHY
  • EMBRYONIC STEM-CELLS
  • DISSOCIATED NEURONS
  • MICROARRAYS
  • SURFACES
  • ADHESION
  • DIFFERENTIATION
  • CULTURE
  • MICROENVIRONMENT

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