In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue

J Sutinen, K Kannisto, E Korsheninnikova, T Nyman, E Ehrenborg, R Andrew, D J Wake, A Hamsten, B R Walker, H Yki-Järvinen

Research output: Contribution to journalArticlepeer-review

Abstract

Highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus (HIV) is associated with a poorly understood lipodystrophic and hypertriglyceridaemic syndrome, which resembles Cushing's syndrome, but in which plasma cortisol is not elevated. We tested the hypothesis that this HAART-associated lipodystrophy is explained by increased local regeneration of cortisol from inactive cortisone within adipose tissue, catalysed by the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).
Original languageEnglish
Pages (from-to)1668-71
Number of pages4
JournalDiabetologia
Volume47
Issue number10
DOIs
Publication statusPublished - 29 Sep 2004

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