In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue

J Sutinen; K Kannisto; E Korsheninnikova; T Nyman; E Ehrenborg; R Andrew; D J Wake; A Hamsten; B R Walker; H Yki-Järvinen

doi:10.1007/s00125-004-1508-2

In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue

J Sutinen, K Kannisto, E Korsheninnikova, T Nyman, E Ehrenborg, R Andrew, D J Wake, A Hamsten, B R Walker, H Yki-Järvinen

Research output: Contribution to journal › Article › peer-review

Abstract

Highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus (HIV) is associated with a poorly understood lipodystrophic and hypertriglyceridaemic syndrome, which resembles Cushing's syndrome, but in which plasma cortisol is not elevated. We tested the hypothesis that this HAART-associated lipodystrophy is explained by increased local regeneration of cortisol from inactive cortisone within adipose tissue, catalysed by the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).

Original language	English
Pages (from-to)	1668-71
Number of pages	4
Journal	Diabetologia
Volume	47
Issue number	10
DOIs	https://doi.org/10.1007/s00125-004-1508-2
Publication status	Published - 29 Sept 2004

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Sutinen, J., Kannisto, K., Korsheninnikova, E., Nyman, T., Ehrenborg, E., Andrew, R., Wake, D. J., Hamsten, A., Walker, B. R., & Yki-Järvinen, H. (2004). In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue. Diabetologia, 47(10), 1668-71. https://doi.org/10.1007/s00125-004-1508-2

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title = "In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue",

abstract = "Highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus (HIV) is associated with a poorly understood lipodystrophic and hypertriglyceridaemic syndrome, which resembles Cushing's syndrome, but in which plasma cortisol is not elevated. We tested the hypothesis that this HAART-associated lipodystrophy is explained by increased local regeneration of cortisol from inactive cortisone within adipose tissue, catalysed by the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).",

author = "J Sutinen and K Kannisto and E Korsheninnikova and T Nyman and E Ehrenborg and R Andrew and Wake, {D J} and A Hamsten and Walker, {B R} and H Yki-J{\"a}rvinen",

year = "2004",

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doi = "10.1007/s00125-004-1508-2",

language = "English",

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Sutinen, J, Kannisto, K, Korsheninnikova, E, Nyman, T, Ehrenborg, E, Andrew, R , Wake, DJ, Hamsten, A, Walker, BR & Yki-Järvinen, H 2004, 'In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue', Diabetologia, vol. 47, no. 10, pp. 1668-71. https://doi.org/10.1007/s00125-004-1508-2

In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue. / Sutinen, J; Kannisto, K; Korsheninnikova, E et al.
In: Diabetologia, Vol. 47, No. 10, 29.09.2004, p. 1668-71.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue

AU - Sutinen, J

AU - Kannisto, K

AU - Korsheninnikova, E

AU - Nyman, T

AU - Ehrenborg, E

AU - Andrew, R

AU - Wake, D J

AU - Hamsten, A

AU - Walker, B R

AU - Yki-Järvinen, H

PY - 2004/9/29

Y1 - 2004/9/29

N2 - Highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus (HIV) is associated with a poorly understood lipodystrophic and hypertriglyceridaemic syndrome, which resembles Cushing's syndrome, but in which plasma cortisol is not elevated. We tested the hypothesis that this HAART-associated lipodystrophy is explained by increased local regeneration of cortisol from inactive cortisone within adipose tissue, catalysed by the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).

AB - Highly active antiretroviral therapy (HAART) in patients infected with human immunodeficiency virus (HIV) is associated with a poorly understood lipodystrophic and hypertriglyceridaemic syndrome, which resembles Cushing's syndrome, but in which plasma cortisol is not elevated. We tested the hypothesis that this HAART-associated lipodystrophy is explained by increased local regeneration of cortisol from inactive cortisone within adipose tissue, catalysed by the enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11beta-HSD1).

UR - http://dx.doi.org/10.1007/s00125-004-1508-2

U2 - 10.1007/s00125-004-1508-2

DO - 10.1007/s00125-004-1508-2

M3 - Article

C2 - 15455200

SN - 0012-186X

VL - 47

SP - 1668

EP - 1671

JO - Diabetologia

JF - Diabetologia

IS - 10

ER -

Sutinen J, Kannisto K, Korsheninnikova E, Nyman T, Ehrenborg E, Andrew R et al. In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue. Diabetologia. 2004 Sept 29;47(10):1668-71. doi: 10.1007/s00125-004-1508-2

In the lipodystrophy associated with highly active antiretroviral therapy, pseudo-Cushing's syndrome is associated with increased regeneration of cortisol by 11beta-hydroxysteroid dehydrogenase type 1 in adipose tissue

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