In vitro 40MHz ultrasonic characterisation of inhouse liposomal dispersions developed for targeting atherosclerotic plaque

CM Moran, J Ross, C Cunningham, M Butler, WN McDicken

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

This paper describes the measurement of the acoustical properties of an in-house contrast agent at 40MHz. In addition, it compares the measured acoustical properties from the agent to three commercial agents (Definity, Optison and SonoVue) at 40MHz. A Boston Scientific Clear-View Ultra intravascular ultrasound scanner with a 40MHz, 2.5Fr Atlantis SR Plus catheter is used.

Mean backscatter power was measured and referenced to the echo from a water-air interface. Mean backscatter power from the in-house ultrasonic contrast agent was found to be -20.53 +/- 0.39dB at 40MHz. Measured mean backscatter power at 40MHz for Definity, Optison and SonoVue was -25.7dB +/- 2.6, -26.9 +/- 2.2dB and -25.07 +/- 1.5dB respectively.

Original languageEnglish
Title of host publication2004 IEEE Ultrasonics Symposium, Vols 1-3
EditorsMP Yuhas
Place of PublicationNEW YORK
PublisherInstitute of Electrical and Electronics Engineers (IEEE)
Pages1395-1397
Number of pages3
ISBN (Print)0-7803-8413-X
Publication statusPublished - 2004
EventIEEE Ultrasonics Symposium - Montreal, Canada
Duration: 23 Aug 200427 Aug 2004

Publication series

NameULTRASONICS SYMPOSIUM
PublisherIEEE
ISSN (Print)1051-0117

Conference

ConferenceIEEE Ultrasonics Symposium
CountryCanada
Period23/08/0427/08/04

Keywords

  • component
  • ultrasonic contrast agents
  • high frequency
  • CONTRAST AGENT

Cite this