In vitro acid exposure has a differential effect on apoptotic and proliferative pathways in a Barrett's adenocarcinoma cell line

Claire Morgan, William Alazawi, Pierre Sirieix, Tom Freeman, Nicholas Coleman, Rebecca Fitzgerald

Research output: Contribution to journalArticlepeer-review

Abstract

Acid, a principal component of refluxate, may contribute to the neoplastic progression of Barrett's esophagus. Brief acid exposure in vivo and in vitro has been shown to increase cell proliferation. The mechanisms underlying the hyperproliferative response are not well elucidated but may include alterations in Na(+)-H+ exchanger activity and MAPK signaling pathways.
Original languageEnglish
Pages (from-to)218-24
Number of pages7
JournalThe American Journal of Gastroenterology
Volume99
Issue number2
Publication statusPublished - Feb 2004

Keywords

  • Adenocarcinoma
  • Apoptosis
  • Barrett Esophagus
  • Caspase 3
  • Caspases
  • Cell Cycle
  • Cell Division
  • Cell Line, Tumor
  • Cell Transformation, Neoplastic
  • Esophageal Neoplasms
  • Gene Expression
  • Humans
  • Hydrochloric Acid
  • MAP Kinase Signaling System
  • Oligonucleotide Array Sequence Analysis

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