In vitro examination of suspicious oral lesions using optical coherence tomography

Waseem Jerjes; Tahwinder Upile; Brendan Conn; Zaid Hamdoon; Christian S Betz; Gordon McKenzie; Hani Radhi; Michael Vourvachis; Mohammed El Maaytah; Ann Sandison; Amrita Jay; Colin Hopper

doi:10.1016/j.bjoms.2009.04.019

In vitro examination of suspicious oral lesions using optical coherence tomography

Waseem Jerjes, Tahwinder Upile, Brendan Conn, Zaid Hamdoon, Christian S Betz, Gordon McKenzie, Hani Radhi, Michael Vourvachis, Mohammed El Maaytah, Ann Sandison, Amrita Jay, Colin Hopper

Research output: Contribution to journal › Article › peer-review

Abstract / Description of output

We compared findings of optical coherence tomography (OCT) with histopathological results of suspicious oral lesions to assess the feasibility of using OCT to identify malignant tissue. Thirty-four oral lesions from 27 patients had swept-source frequency-domain OCT. Four variables were assessed (changes in keratin, epithelial, and sub-epithelial layers, and identification of the basement membrane) and from this we calculated whether or not there were architectural changes. These data were then compared with histopathological results. Two clinicians, who were unaware of the clinical and histopathological diagnoses, decided whether biopsy was necessary. The basement membrane was recognised in only 15 oral lesions. OCT could identify diseased areas but could not provide a diagnosis or differentiate between lesions. The two clinicians, who recommended biopsy agreed in all cases. This pilot study confirms the feasibility of using OCT to identify architectural changes in malignant tissues.

Original language	English
Pages (from-to)	18-25
Number of pages	8
Journal	British Journal of Oral and Maxillofacial Surgery
Volume	48
Issue number	1
DOIs	https://doi.org/10.1016/j.bjoms.2009.04.019
Publication status	Published - Jan 2010
Externally published	Yes

Keywords / Materials (for Non-textual outputs)

Basement Membrane
Biopsy
Carcinoma, Squamous Cell
Diagnosis, Differential
Epithelium
Erythroplasia
Feasibility Studies
Humans
Image Processing, Computer-Assisted
Keratins
Leukoplakia, Oral
Mouth Mucosa
Mouth Neoplasms
Oral Ulcer
Pilot Projects
Precancerous Conditions
Tomography, Optical Coherence
Tongue Neoplasms

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10.1016/j.bjoms.2009.04.019

Cite this

@article{bf66e2fd47294313bb70d27427bb6918,

title = "In vitro examination of suspicious oral lesions using optical coherence tomography",

abstract = "We compared findings of optical coherence tomography (OCT) with histopathological results of suspicious oral lesions to assess the feasibility of using OCT to identify malignant tissue. Thirty-four oral lesions from 27 patients had swept-source frequency-domain OCT. Four variables were assessed (changes in keratin, epithelial, and sub-epithelial layers, and identification of the basement membrane) and from this we calculated whether or not there were architectural changes. These data were then compared with histopathological results. Two clinicians, who were unaware of the clinical and histopathological diagnoses, decided whether biopsy was necessary. The basement membrane was recognised in only 15 oral lesions. OCT could identify diseased areas but could not provide a diagnosis or differentiate between lesions. The two clinicians, who recommended biopsy agreed in all cases. This pilot study confirms the feasibility of using OCT to identify architectural changes in malignant tissues.",

keywords = "Basement Membrane, Biopsy, Carcinoma, Squamous Cell, Diagnosis, Differential, Epithelium, Erythroplasia, Feasibility Studies, Humans, Image Processing, Computer-Assisted, Keratins, Leukoplakia, Oral, Mouth Mucosa, Mouth Neoplasms, Oral Ulcer, Pilot Projects, Precancerous Conditions, Tomography, Optical Coherence, Tongue Neoplasms",

author = "Waseem Jerjes and Tahwinder Upile and Brendan Conn and Zaid Hamdoon and Betz, {Christian S} and Gordon McKenzie and Hani Radhi and Michael Vourvachis and {El Maaytah}, Mohammed and Ann Sandison and Amrita Jay and Colin Hopper",

year = "2010",

month = jan,

doi = "10.1016/j.bjoms.2009.04.019",

language = "English",

volume = "48",

pages = "18--25",

journal = "British Journal of Oral and Maxillofacial Surgery",

issn = "0266-4356",

publisher = "Churchill Livingstone",

number = "1",

}

TY - JOUR

T1 - In vitro examination of suspicious oral lesions using optical coherence tomography

AU - Jerjes, Waseem

AU - Upile, Tahwinder

AU - Conn, Brendan

AU - Hamdoon, Zaid

AU - Betz, Christian S

AU - McKenzie, Gordon

AU - Radhi, Hani

AU - Vourvachis, Michael

AU - El Maaytah, Mohammed

AU - Sandison, Ann

AU - Jay, Amrita

AU - Hopper, Colin

PY - 2010/1

Y1 - 2010/1

N2 - We compared findings of optical coherence tomography (OCT) with histopathological results of suspicious oral lesions to assess the feasibility of using OCT to identify malignant tissue. Thirty-four oral lesions from 27 patients had swept-source frequency-domain OCT. Four variables were assessed (changes in keratin, epithelial, and sub-epithelial layers, and identification of the basement membrane) and from this we calculated whether or not there were architectural changes. These data were then compared with histopathological results. Two clinicians, who were unaware of the clinical and histopathological diagnoses, decided whether biopsy was necessary. The basement membrane was recognised in only 15 oral lesions. OCT could identify diseased areas but could not provide a diagnosis or differentiate between lesions. The two clinicians, who recommended biopsy agreed in all cases. This pilot study confirms the feasibility of using OCT to identify architectural changes in malignant tissues.

AB - We compared findings of optical coherence tomography (OCT) with histopathological results of suspicious oral lesions to assess the feasibility of using OCT to identify malignant tissue. Thirty-four oral lesions from 27 patients had swept-source frequency-domain OCT. Four variables were assessed (changes in keratin, epithelial, and sub-epithelial layers, and identification of the basement membrane) and from this we calculated whether or not there were architectural changes. These data were then compared with histopathological results. Two clinicians, who were unaware of the clinical and histopathological diagnoses, decided whether biopsy was necessary. The basement membrane was recognised in only 15 oral lesions. OCT could identify diseased areas but could not provide a diagnosis or differentiate between lesions. The two clinicians, who recommended biopsy agreed in all cases. This pilot study confirms the feasibility of using OCT to identify architectural changes in malignant tissues.

KW - Basement Membrane

KW - Biopsy

KW - Carcinoma, Squamous Cell

KW - Diagnosis, Differential

KW - Epithelium

KW - Erythroplasia

KW - Feasibility Studies

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Keratins

KW - Leukoplakia, Oral

KW - Mouth Mucosa

KW - Mouth Neoplasms

KW - Oral Ulcer

KW - Pilot Projects

KW - Precancerous Conditions

KW - Tomography, Optical Coherence

KW - Tongue Neoplasms

U2 - 10.1016/j.bjoms.2009.04.019

DO - 10.1016/j.bjoms.2009.04.019

M3 - Article

C2 - 19726114

SN - 0266-4356

VL - 48

SP - 18

EP - 25

JO - British Journal of Oral and Maxillofacial Surgery

JF - British Journal of Oral and Maxillofacial Surgery

IS - 1

ER -

In vitro examination of suspicious oral lesions using optical coherence tomography

Abstract / Description of output

Keywords / Materials (for Non-textual outputs)

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