In Vivo Measurement of Cerebral Mitochondrial Metabolism Using Broadband Near Infrared Spectroscopy Following Neonatal Stroke

Subhabrata Mitra, Gemma Bale, Judith Meek, Sean Mathieson, Cristina Uria, Giles Kendall, Nicola J Robertson, Ilias Tachtsidis

Research output: Contribution to journalArticlepeer-review

Abstract

Neonatal stroke presents with features of encephalopathy and can result in significant morbidity and mortality. We investigated the cerebral metabolic and haemodynamic changes following neonatal stroke in a term infant at 24 h of life. Changes in oxidation state of cytochrome-c-oxidase (oxCCO) concentration were monitored along with changes in oxy- and deoxy- haemoglobin using a new broadband near-infrared spectroscopy (NIRS) system. Repeated transient changes in cerebral haemodynamics and metabolism were noted over a 3-h study period with decrease in oxyhaemoglobin (HbO2), deoxy haemoglobin (HHb) and oxCCO in both cerebral hemispheres without significant changes in systemic observations. A clear asymmetry was noted in the degree of change between the two cerebral hemispheres. Changes in cerebral oxygenation (measured as HbDiff=HbO2-HHb) and cerebral metabolism (measured as oxCCO) were highly coupled on the injured side of the brain.

Original languageEnglish
Pages (from-to)493-500
Number of pages8
JournalAdvances in Experimental Medicine and Biology
Volume876
DOIs
Publication statusPublished - 2016

Keywords

  • Brain/metabolism
  • Electroencephalography
  • Humans
  • Infant, Newborn
  • Mitochondria/metabolism
  • Oxygen/metabolism
  • Spectroscopy, Near-Infrared/methods
  • Stroke/metabolism

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