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Abstract / Description of output
Ideal therapies for regenerative medicine or healthy aging require healthy organ growth and rejuvenation but no organ level approach is currently available. Using Mycobacterium leprae (ML) with natural partial cellular reprogramming capacity and its animal host nine-banded armadillos, we present an evolutionarily refined model of adult liver growth and regeneration. In infected-armadillos, ML reprogram the entire liver and significantly increase total liver: body weight by increasing healthy liver lobules including hepatocyte proliferation and proportionate expansion of vasculature, and biliary systems. ML infected livers are microarchitecturally and functionally normal without damage, fibrosis or tumorigenesis. Bacterial-induced reprogramming reactivates liver progenitor/developmental/fetal genes, and upregulates growth-, metabolism-, and anti-aging-associated markers with minimal change in senescence and tumorigenic genes, suggesting bacterial hijacking of homeostatic, regeneration pathways to promote de novo organogenesis. This may facilitate the unravelling endogenous pathways that effectively and safely re-engage liver organ growth, with broad therapeutic implications including organ regeneration and rejuvenation
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- 1 Finished
The role of mesothelial cells and the p75NTR/sortilin axis in hepatic injury, fibrosis & regeneration
1/10/11 → 30/09/16