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All patients demonstrated increased pulmonary 18F-GP1 uptake at a median of 69 (interquartile range 56-98) days after index presentation despite ongoing therapeutic oral anticoagulation. Focal intravascular uptake in persistent pulmonary embolism (A) was seen, as described previously (5). However, we also noted parenchymal uptake in regions of consolidation (B), as well as systemic uptake in an occluded saphenous vein coronary artery bypass graft and left ventricular thrombus which was subsequently confirmed on echocardiography (C). 18F-GP1 autoradiography also demonstrated focal and specific uptake co-localising to intravascular thrombus in patients with confirmed diffuse alveolar damage (D).
Protracted systemic and pulmonary thrombosis may be a feature of COVID-19 that can persist despite systemic therapeutic anticoagulation. 18F-GP1 is able to detect pulmonary and systemic arterial thrombosis and has potential applications across a broad range of pathologies.
|Journal||American Journal of Respiratory and Critical Care Medicine|
|Publication status||Published - 10 Aug 2021|
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1/10/16 → 31/03/22