In Vivo Tumor Visualization through MRI Off-On Switching of NaGdF4–CaCO3 Nanoconjugates

Zhigao Yi, Zichao Luo, Nicole D Barth, Xianfu Meng, Hong Liu, Wenbo Bu, Angelo All, Marc Vendrell, Xiaogang Liu

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

The development of high-performance contrast agents in magnetic resonance imaging (MRI) has recently received considerable attention, as they hold great promise and potential as a powerful tool for cancer diagnosis. Despite substantial achievements, it remains challenging to develop nanostructure-based biocompatible platforms that can generate on-demand MRI signals with high signal-to-noise ratios and good tumor specificity. In this article, we report the design and synthesis of a new class of nanoparticle-based contrast agents comprising self-assembled NaGdF4 and CaCO3 nanoconjugates. In our design, the spatial confinement of the T1 source (Gd3+ ions) leads to an “OFF” MRI signal due to insufficient interaction between the protons and the crystal lattices. However, when immersed in a mildly acidic tumor microenvironment, the embedded CaCO3 nanoparticles generate CO2 bubbles and subsequently disconnect the nanoconjugate, thus resulting in an “ON” MRI signal. The in vivo performance of this nanoconjugates shows more than 60-fold contrast enhancement in tumor visualization relative to commercially used contrast agent Magnevist. Our work presents a significant advance in the construction of smart MRI nanoprobes ideally suited for deep-tissue imaging and target-specific cancer diagnosis.
Original languageEnglish
Pages (from-to)1-7
JournalAdvanced Materials
Issue number37
Early online date30 Jul 2019
Publication statusPublished - 13 Sept 2019


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