Increase of the spontaneous mutation rate in a long-term experiment with Drosophila melanogaster

Victoria Avila, D Chavarrias, Enrique Sanchez Molano, A Manrique, C Lopez-Fanjul, Aurora García-Dorado

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

In a previous experiment, the effect of 255 generations of mutation accumulation (MA) on the second chromosome viability of Drosophila melanogaster was studied using 200 full-sib MA1 lines and a large C1 control, both derived from a genetically homogeneous base population. At generation 265, one of those MA1 lines was expanded to start 150 new full-sib MA2 lines and a new C2 large control. After 46 generations, the rate of decline in mean viability in MA2 was similar to 2.5 times that estimated in MA1, while the average degree of dominance of mutations was small and nonsignificant by generation 40 and moderate by generation 80. In parallel, the inbreeding depression rate for viability and the amount of additive variance for two bristle traits in C2 were 2-3 times larger than those in Cl. The results are consistent with a mutation rate in the line from which MA2 and C2 were derived about 2.5 times larger than that in MAL The mean viability of C2 remained roughly similar to that of C1, but the rate of MA2 line extinction increased progressively, leading to mutational collapse, which can be ascribed to accelerated mutation and/or synergy after important deleterious accumulation.

Original languageEnglish
Pages (from-to)267-277
Number of pages11
JournalGenetics
Volume173
Issue number1
DOIs
Publication statusPublished - May 2006

Keywords / Materials (for Non-textual outputs)

  • POLYGENES CONTROLLING VIABILITY
  • GENETIC-STRUCTURE
  • NATURAL-POPULATIONS
  • DELETERIOUS MUTATIONS
  • SYNERGISTIC EPISTASIS
  • QUANTITATIVE TRAITS
  • FITNESS
  • ACCUMULATION
  • SIMULATION
  • VARIABILITY

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