Increased Abundance of M cells in the Gut Epithelium Dramatically Enhances Oral Prion Disease Susceptibility

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• Finished

  US-A transatlantic partnership to identify novel factors that influence the development and function of M cells in the gut epithelium

  Mabbott, N. (Principal Investigator)

  BBSRC

  30/07/13 → 1/06/18

  Project: Research

  • Microfold Cell 100%
  • Intestinal Epithelium 100%
  • Peyer's Patch 76%
  • Maturation 70%
  • Mucosal Immune System 62%

• Determining the role of m cells in tse agent neuroinvasion from the intestine

  Mabbott, N. (Principal Investigator) & Mahajan, A. (Co-investigator)

  BBSRC

  1/11/12 → 31/03/16

  Project: Research

  • Microfold Cell 100%
  • Transmissible Spongiform Encephalopathy 72%
  • Macrophage 72%
  • Peyer's Patch 68%
  • Prion Protein 67%

• Eastbio Doctoral Training Partnership

  Mabbott, N. (Principal Investigator) & Gill, A. (Co-investigator)

  BBSRC

  1/10/12 → 30/09/16

  Project: Research

  • Microfold Cell 100%
  • Transmissible Spongiform Encephalopathy 50%
  • Intestinal Epithelium 50%
  • Follicle 50%
  • Maturation 50%

• Livestock neurobiology

  Gill, A. (Principal Investigator), Barron, R. (Co-investigator), Beard, P. (Co-investigator), Brunton, P. (Co-investigator), Goldmann, W. (Co-investigator), Hume, D. (Co-investigator), Hunter, N. (Co-investigator), Lawrence, A. (Co-investigator), Mabbott, N. (Co-investigator), Manson, J. (Co-investigator), McColl, B. (Co-investigator), Meddle, S. (Co-investigator) & Wishart, T. (Co-investigator)

  BBSRC

  1/04/12 → 31/03/17

  Project: Research

  • Prion Protein 100%
  • Transmissible Spongiform Encephalopathy 57%
  • Prenatal Stress 51%
  • Messenger RNA 47%
  • Amyloid Protein 36%

• Innate immunity and endemic diseases in livestock species

  Collie, D. (Principal Investigator), Beard, P. (Co-investigator), Bishop, S. (Co-investigator), Bronsvoort, M. (Co-investigator), Burt, D. (Co-investigator), Fitzgerald, R. (Co-investigator), Freeman, T. (Co-investigator), Gally, D. (Co-investigator), Gill, A. (Co-investigator), Glass, E. (Co-investigator), Hocking, P. (Co-investigator), Hope, J. (Co-investigator), Hume, D. (Co-investigator), Kaiser, P. (Co-investigator), Mabbott, N. (Co-investigator), McLachlan, G. (Co-investigator), Morrison, L. (Co-investigator), Stevens, J. (Co-investigator), Stevens, M. (Co-investigator) & Watson, M. (Co-investigator)

  BBSRC

  1/04/12 → 31/03/17

  Project: Research

  • Macrophage 100%
  • Infectious Agent 64%
  • T Cell 39%
  • Immune Response 32%
  • Gene Expression 31%