Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke

Barry W. McColl; Nicola Rose; Fiona H. Robson; Nancy J. Rothwell; Catherine B. Lawrence

doi:10.1038/jcbfm.2009.217

Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke

Barry W. McColl, Nicola Rose, Fiona H. Robson, Nancy J. Rothwell, Catherine B. Lawrence

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Abstract / Description of output

Obesity is an independent risk factor for stroke and is associated with poorer outcome after stroke. We investigated whether this poorer outcome is related to brain microvascular disruption. Focal cerebral ischaemia was induced in lean or obese (ob/ob) mice by transient middle cerebral artery occlusion. The incidence of haemorrhagic transformation and the volume of ischaemic brain damage were significantly greater in obese mice. Blood-brain barrier permeability and brain microvascular MMP-9 expression were also markedly increased in obese mice. These effects were independent of leptin or glycaemic status, suggesting that obesity potentiates brain microvascular disruption after experimental stroke. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 267-272; doi: 10.1038/jcbfm.2009.217; published online 14 October 2009

Original language	English
Pages (from-to)	267-272
Number of pages	6
Journal	Journal of Cerebral Blood Flow and Metabolism
Volume	30
Issue number	2
DOIs	https://doi.org/10.1038/jcbfm.2009.217
Publication status	Published - Feb 2010

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Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental strokeFinal published version, 363 KB

http://www.nature.com/jcbfm/journal/v30/n2/full/jcbfm2009217a.html

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title = "Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke",

abstract = "Obesity is an independent risk factor for stroke and is associated with poorer outcome after stroke. We investigated whether this poorer outcome is related to brain microvascular disruption. Focal cerebral ischaemia was induced in lean or obese (ob/ob) mice by transient middle cerebral artery occlusion. The incidence of haemorrhagic transformation and the volume of ischaemic brain damage were significantly greater in obese mice. Blood-brain barrier permeability and brain microvascular MMP-9 expression were also markedly increased in obese mice. These effects were independent of leptin or glycaemic status, suggesting that obesity potentiates brain microvascular disruption after experimental stroke. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 267-272; doi: 10.1038/jcbfm.2009.217; published online 14 October 2009",

author = "McColl, {Barry W.} and Nicola Rose and Robson, {Fiona H.} and Rothwell, {Nancy J.} and Lawrence, {Catherine B.}",

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AU - McColl, Barry W.

AU - Rose, Nicola

AU - Robson, Fiona H.

AU - Rothwell, Nancy J.

AU - Lawrence, Catherine B.

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N2 - Obesity is an independent risk factor for stroke and is associated with poorer outcome after stroke. We investigated whether this poorer outcome is related to brain microvascular disruption. Focal cerebral ischaemia was induced in lean or obese (ob/ob) mice by transient middle cerebral artery occlusion. The incidence of haemorrhagic transformation and the volume of ischaemic brain damage were significantly greater in obese mice. Blood-brain barrier permeability and brain microvascular MMP-9 expression were also markedly increased in obese mice. These effects were independent of leptin or glycaemic status, suggesting that obesity potentiates brain microvascular disruption after experimental stroke. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 267-272; doi: 10.1038/jcbfm.2009.217; published online 14 October 2009

AB - Obesity is an independent risk factor for stroke and is associated with poorer outcome after stroke. We investigated whether this poorer outcome is related to brain microvascular disruption. Focal cerebral ischaemia was induced in lean or obese (ob/ob) mice by transient middle cerebral artery occlusion. The incidence of haemorrhagic transformation and the volume of ischaemic brain damage were significantly greater in obese mice. Blood-brain barrier permeability and brain microvascular MMP-9 expression were also markedly increased in obese mice. These effects were independent of leptin or glycaemic status, suggesting that obesity potentiates brain microvascular disruption after experimental stroke. Journal of Cerebral Blood Flow & Metabolism (2010) 30, 267-272; doi: 10.1038/jcbfm.2009.217; published online 14 October 2009

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Increased brain microvascular MMP-9 and incidence of haemorrhagic transformation in obese mice after experimental stroke

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