Increased CD40 ligand and platelet-monocyte aggregates in patients with type 1 diabetes mellitus

S A Harding, A J Sommerfield, J Sarma, P J Twomey, D E Newby, B M Frier, K A A Fox

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

BACKGROUND: Diabetes mellitus is a major risk factor for cardiovascular disease and is associated with a proinflammatory and prothrombotic state. We investigated whether CD40 ligand (L) expression and platelet-monocyte aggregation are increased in patients with type 1 diabetes.

METHODS: Serum C-reactive protein (CRP) and soluble (s) CD40L concentrations, platelet surface CD40L expression and platelet-monocyte aggregates were measured in 22 patients with uncomplicated type 1 diabetes and 22 age- and sex-matched non-diabetic control subjects.

RESULTS: In comparison to controls, patients with type 1 diabetes had higher serum CRP concentrations (3.29 +/- 0.9 mg/L versus 0.99 +/- 0.2mg/L, P = 0.01), serum sCD40L concentrations (10.0 +/- 1.4 ng/mL versus 4.6 +/- 0.6 ng/mL, P = 0.006), and platelet surface expression of CD40L (13.8 +/- 0.9% versus 8.5 +/- 1.1%, P < 0.001). Platelet-monocyte aggregates were also significantly elevated in type 1 diabetes (35.9 +/- 3.3% versus 26.4 +/- 2.9%, P = 0.005; n = 10). We also observed a significant correlation between plasma glucose and serum CRP (r = 0.53, P = 0.01) as well as platelet-monocyte aggregates (r = 0.69, P = 0.03).

CONCLUSIONS: Type 1 diabetes is associated with increased CD40L expression and platelet-monocyte aggregation, which may contribute to the proinflammatory and prothrombotic state as well as the accelerated atherogenesis associated with this disorder.

Original languageEnglish
Pages (from-to)321-5
Number of pages5
Issue number2
Publication statusPublished - Oct 2004

Keywords / Materials (for Non-textual outputs)

  • Adult
  • Blood Glucose
  • C-Reactive Protein
  • CD40 Ligand
  • Cardiovascular Diseases
  • Case-Control Studies
  • Diabetes Complications
  • Diabetes Mellitus, Type 1
  • Female
  • Humans
  • Inflammation
  • Male
  • Monocytes
  • Platelet Aggregation


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