Increased clearance of cortisol by 5beta-reductase in a subgroup of women with adrenal hyperandrogenism in polycystic ovary syndrome

A Gambineri, G Forlani, A Munarini, F Tomassoni, G E Cognigni, W Ciampaglia, U Pagotto, B R Walker, R Pasquali

Research output: Contribution to journalArticlepeer-review

Abstract

Increased peripheral metabolism of cortisol may explain compensatory ACTH-dependent adrenal steroidogenesis and hence hyperandrogenism in polycystic ovary syndrome (PCOS). Previous studies have described an increased 5alpha-reduction of cortisol or impaired regeneration of cortisol by 11beta-HSD1 in PCOS. However, these observations may be confounded by obesity. Moreover, the relationship between alterations in cortisol metabolism and the extent of adrenal androgen hyper-secretion in response to ACTH has not been established. This study aimed to examine the association between cortisol metabolism and ACTH-dependent adrenal hyperandrogenism in PCOS, independently of obesity.
Original languageEnglish
Pages (from-to)210-8
Number of pages9
JournalJournal of Endocrinological Investigation
Volume32
Issue number3
Publication statusPublished - 2009

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