Abstract
The expression of activated forms of key proteins of the DNA damage response machinery (pNBS1, pATM and gamma H2AX) was assessed by means of immunohistochemistry in bone marrow biopsies of 74 patients with de novo myelodysplastic syndromes (MDS) and compared with 15 cases of de novo acute myeloid leukemia (AML) and 20 with reactive bone marrow histology. Expression levels were significantly increased in both MDS and AML, compared to controls, being higher in high-risk than in low-risk MDS. Increased pNBS1 and gamma H2AX expression possessed a significant negative prognostic impact for overall survival in MDS patients, whereas pNBS1 was an independent marker of poor prognosis. (C) 2013 Elsevier Ltd. All rights reserved.
Original language | English |
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Pages (from-to) | 1576-1582 |
Number of pages | 7 |
Journal | Leukemia Research |
Volume | 37 |
Issue number | 11 |
Early online date | 5 Sept 2013 |
DOIs | |
Publication status | Published - Nov 2013 |
Keywords / Materials (for Non-textual outputs)
- Myelodysplastic syndromes
- DNA damage response
- pNBS1
- pATM
- gamma H2AX
- ACUTE MYELOID-LEUKEMIA
- MYOGENIC DIFFERENTIATION
- GENETIC INSTABILITY
- BONE-MARROW
- CELLS
- COMPLEX
- CANCER
- ABNORMALITIES
- ACTIVATION
- ANEUPLOIDY