Increased IL-23 secretion and altered chemokine production by dendritic cells upon CD46 activation in patients with multiple sclerosis

Adi Vaknin-Dembinsky, Gopal Murugaiyan, David A Hafler, Anne L Astier, Howard L Weiner

Research output: Contribution to journalArticlepeer-review

Abstract

Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system (CNS). In MS, myeloid dendritic cells (mDCs) secrete elevated amounts of IL-23, a potent proinflammatory cytokine, compared to healthy donors. Here, we examined the role of CD46, a complement binding factor, in mDCs by analyzing cytokine and chemokine production in healthy donors and patients with MS. There were striking differences between these groups with increased IL-23p19, CCL3 and CCL5 production, but decreased CCL2 levels in patients. This demonstrates major differences of DC activation upon CD46 activation, with a potential role in the pathogenesis of MS.
Original languageEnglish
Pages (from-to)140-5
Number of pages6
JournalJournal of Neuroimmunology
Volume195
Issue number1-2
DOIs
Publication statusPublished - Mar 2008

Keywords

  • Adult
  • Antigens, CD46
  • Chemokines
  • Dendritic Cells
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Interleukin-23
  • Lipopolysaccharides
  • Lymphocyte Activation
  • Male
  • Middle Aged
  • Multiple Sclerosis
  • Statistics, Nonparametric

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