Increased large conductance calcium-activated potassium (BK) channel expression accompanied by STREX variant downregulation in the developing mouse CNS

Stephen H-F MacDonald, Peter Ruth, Hans-Guenther Knaus, Michael J Shipston

Research output: Contribution to journalArticlepeer-review

Abstract

Large conductance calcium- and voltage activated potassium (BK) channels are important determinants of neuronal excitability through effects on action potential duration, frequency and synaptic efficacy. The pore- forming subunits are encoded by a single gene, KCNMA1, which undergoes extensive alternative pre mRNA splicing. Different splice variants can confer distinct properties on BK channels. For example, insertion of the 58 amino acid stress-regulated exon (STREX) insert, that is conserved throughout vertebrate evolution, encodes channels with distinct calcium sensitivity and regulation by diverse signalling pathways compared to the insertless (ZERO) variant. Thus, expression of distinct splice variants may allow cells to differentially shape their electrical properties during development. However, whether differential splicing of BK channel variants occurs during development of the mammalian CNS has not been examined.
Original languageEnglish
Pages (from-to)37
JournalBMC Developmental Biology
Volume6
DOIs
Publication statusPublished - 2006

Keywords

  • Animals
  • Genetic Variation
  • Spinal Cord
  • Exons
  • Brain
  • Large-Conductance Calcium-Activated Potassium Channels
  • Mice
  • Central Nervous System
  • RNA, Messenger
  • Animals, Newborn
  • Down-Regulation
  • Alternative Splicing
  • Mice, Inbred C57BL
  • Gene Expression Regulation, Developmental

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