Increased Skeletal Muscle 11βHSD1 mRNA Is Associated with Lower Muscle Strength in Ageing

Alixe H M Kilgour; Iain J Gallagher; Alasdair M J Maclullich; Ruth Andrew; Calum D Gray; Philippa Hyde; Henning Wackerhage; Holger Husi; James A Ross; John M Starr; Karen E Chapman; Kenneth C H Fearon; Brian R Walker; Carolyn A Greig

doi:10.1371/journal.pone.0084057

Increased Skeletal Muscle 11βHSD1 mRNA Is Associated with Lower Muscle Strength in Ageing

Alixe H M Kilgour, Iain J Gallagher, Alasdair M J Maclullich, Ruth Andrew, Calum D Gray, Philippa Hyde, Henning Wackerhage, Holger Husi, James A Ross, John M Starr, Karen E Chapman, Kenneth C H Fearon, Brian R Walker, Carolyn A Greig

Research output: Contribution to journal › Article › peer-review

Abstract

Sarcopenia, the loss of muscle mass and function with age, is associated with increased morbidity and mortality. Current understanding of the underlying mechanisms is limited. Glucocorticoids (GC) in excess cause muscle weakness and atrophy. We hypothesized that GC may contribute to sarcopenia through elevated circulating levels or increased glucocorticoid receptor (GR) signaling by increased expression of either GR or the GC-amplifying enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11βHSD1) in muscle.

Original language	English
Pages (from-to)	e84057
Journal	PLoS ONE
Volume	8
Issue number	12
DOIs	https://doi.org/10.1371/journal.pone.0084057
Publication status	Published - 31 Dec 2013

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10.1371/journal.pone.0084057

Increased Skeletal Muscle 11βHSD1 mRNA Is Associated with Lower Muscle Strength in Ageing
Copyright: © 2013 Kilgour et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0084057

MRC Centre for Cognitive Ageing and Cognitive Epidemiology
Deary, I., Holmes, M., Logie, P., McCulloch, J., Porteous, D., Roberts, N., Seckl, J., Starr, J. & Wardlaw, J.
MRC
1/09/08 → 31/08/13
Project: Research

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Kilgour, A. H. M., Gallagher, I. J., Maclullich, A. M. J., Andrew, R., Gray, C. D., Hyde, P., Wackerhage, H., Husi, H., Ross, J. A., Starr, J. M., Chapman, K. E., Fearon, K. C. H., Walker, B. R., & Greig, C. A. (2013). Increased Skeletal Muscle 11βHSD1 mRNA Is Associated with Lower Muscle Strength in Ageing. PLoS ONE, 8(12), e84057. https://doi.org/10.1371/journal.pone.0084057

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title = "Increased Skeletal Muscle 11βHSD1 mRNA Is Associated with Lower Muscle Strength in Ageing",

abstract = "Sarcopenia, the loss of muscle mass and function with age, is associated with increased morbidity and mortality. Current understanding of the underlying mechanisms is limited. Glucocorticoids (GC) in excess cause muscle weakness and atrophy. We hypothesized that GC may contribute to sarcopenia through elevated circulating levels or increased glucocorticoid receptor (GR) signaling by increased expression of either GR or the GC-amplifying enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11βHSD1) in muscle.",

author = "Kilgour, {Alixe H M} and Gallagher, {Iain J} and Maclullich, {Alasdair M J} and Ruth Andrew and Gray, {Calum D} and Philippa Hyde and Henning Wackerhage and Holger Husi and Ross, {James A} and Starr, {John M} and Chapman, {Karen E} and Fearon, {Kenneth C H} and Walker, {Brian R} and Greig, {Carolyn A}",

note = "Funding: The authors thank the British Heart Foundation and Chief Scientist Office of the Scottish Government for financial support. AHJK, AMJM and JMS are members of The University of Edinburgh Centre for Cognitive Ageing and Cognitive Epidemiology, part of the cross council Lifelong Health and Wellbeing Initiative. Funding from the BBSRC, EPSRC, ESRC and MRC is gratefully acknowledged. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.",

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AU - Kilgour, Alixe H M

AU - Gallagher, Iain J

AU - Maclullich, Alasdair M J

AU - Andrew, Ruth

AU - Gray, Calum D

AU - Hyde, Philippa

AU - Wackerhage, Henning

AU - Husi, Holger

AU - Ross, James A

AU - Starr, John M

AU - Chapman, Karen E

AU - Fearon, Kenneth C H

AU - Walker, Brian R

AU - Greig, Carolyn A

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PY - 2013/12/31

Y1 - 2013/12/31

N2 - Sarcopenia, the loss of muscle mass and function with age, is associated with increased morbidity and mortality. Current understanding of the underlying mechanisms is limited. Glucocorticoids (GC) in excess cause muscle weakness and atrophy. We hypothesized that GC may contribute to sarcopenia through elevated circulating levels or increased glucocorticoid receptor (GR) signaling by increased expression of either GR or the GC-amplifying enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11βHSD1) in muscle.

AB - Sarcopenia, the loss of muscle mass and function with age, is associated with increased morbidity and mortality. Current understanding of the underlying mechanisms is limited. Glucocorticoids (GC) in excess cause muscle weakness and atrophy. We hypothesized that GC may contribute to sarcopenia through elevated circulating levels or increased glucocorticoid receptor (GR) signaling by increased expression of either GR or the GC-amplifying enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11βHSD1) in muscle.

U2 - 10.1371/journal.pone.0084057

DO - 10.1371/journal.pone.0084057

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Increased Skeletal Muscle 11βHSD1 mRNA Is Associated with Lower Muscle Strength in Ageing

Abstract

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MRC Centre for Cognitive Ageing and Cognitive Epidemiology

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