Increased Skeletal Muscle 11βHSD1 mRNA Is Associated with Lower Muscle Strength in Ageing

Alixe H M Kilgour, Iain J Gallagher, Alasdair M J Maclullich, Ruth Andrew, Calum D Gray, Philippa Hyde, Henning Wackerhage, Holger Husi, James A Ross, John M Starr, Karen E Chapman, Kenneth C H Fearon, Brian R Walker, Carolyn A Greig

Research output: Contribution to journalArticlepeer-review

Abstract / Description of output

Sarcopenia, the loss of muscle mass and function with age, is associated with increased morbidity and mortality. Current understanding of the underlying mechanisms is limited. Glucocorticoids (GC) in excess cause muscle weakness and atrophy. We hypothesized that GC may contribute to sarcopenia through elevated circulating levels or increased glucocorticoid receptor (GR) signaling by increased expression of either GR or the GC-amplifying enzyme 11beta-hydroxysteroid dehydrogenase type 1 (11βHSD1) in muscle.
Original languageEnglish
Pages (from-to)e84057
JournalPLoS ONE
Volume8
Issue number12
DOIs
Publication statusPublished - 31 Dec 2013

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