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Trichuris muris is a natural mouse helminth pathogen which establishes infection specifically in the caecum and proximal colon. The rapid expulsion of T. muris in resistant mouse strains is associated with the induction of a protective T helper cell type 2 (Th2)-polarised immune response. Susceptible mouse strains, in contrast, mount an inappropriate Th1 response to T. muris infection. Expression of the chemokine CXCL13 by stromal follicular dendritic cells attracts CXCR5-expressing cells towards the B cell follicles. Previous studies using a complex in vivo depletion model have suggested that CXCR5-expressing conventional dendritic cells (cDC) help regulate the induction of Th2-polarized responses. Here, transgenic with CXCR5- deficiency specifically restricted to CD11c+ cells were used to determine whether the specific absence CXCR5 on CD11c+ cells such as cDC would influence susceptibility to oral T. muris
- Trichuris muris
- dendritic cell
FingerprintDive into the research topics of 'Increased susceptibility to oral Trichuris muris infection in the specific absence of CXCR5+ CD11c+ cells'. Together they form a unique fingerprint.
- 1 Article
CSF-1 receptor-mediated differentiation of a new type of monocytic cell with B cell-stimulating activity: its selective dependence on IL-34Yamane, F., Nishikawa, Y., Matsui, K., Asakura, M., Iwasaki, E., Watanabe, K., Tanimoto, H., Sano, H., Fujiwara, Y., Stanley, E. R., Kanayama, N., Mabbott, N. A., Magari, M. & Ohmori, H., Jan 2014, In: Journal of Leukocyte Biology. 95, 1, p. 19-31
Research output: Contribution to journal › Article › peer-review