Increased susceptibility to oral Trichuris muris infection in the specific absence of CXCR5+ CD11c+ cells

Barry Bradford, David Donaldson, Ruth Forman, Kathryn Else, Neil Mabbott

Research output: Contribution to journalArticlepeer-review

Abstract

Trichuris muris is a natural mouse helminth pathogen which establishes infection specifically in the caecum and proximal colon. The rapid expulsion of T. muris in resistant mouse strains is associated with the induction of a protective T helper cell type 2 (Th2)-polarised immune response. Susceptible mouse strains, in contrast, mount an inappropriate Th1 response to T. muris infection. Expression of the chemokine CXCL13 by stromal follicular dendritic cells attracts CXCR5-expressing cells towards the B cell follicles. Previous studies using a complex in vivo depletion model have suggested that CXCR5-expressing conventional dendritic cells (cDC) help regulate the induction of Th2-polarized responses. Here, transgenic with CXCR5- deficiency specifically restricted to CD11c+ cells were used to determine whether the specific absence CXCR5 on CD11c+ cells such as cDC would influence susceptibility to oral T. muris
Original languageEnglish
Article numbere12566
JournalParasite Immunology
Volume40
Issue number8
Early online date19 Jun 2018
DOIs
Publication statusPublished - Aug 2018

Keywords

  • Trichuris muris
  • helminth
  • dendritic cell
  • CXCR5
  • ntestine
  • mucosal

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