Indocyanine green clearance reflects reperfusion injury following liver transplantation and is an early predictor of graft function

JN Plevris*, R Jalan, KI Bzeizi, MM Dollinger, A Lee, OJ Garden, PC Hayes

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background/Aims: Primary graft dysfunction is difficult to predict. We have previously shown that indocyanine green clearance measured at 24 h following orthotopic liver transplantation predicts graft survival and outcome. We prospectively evaluated the use of indocyanine green clearance (with a cut-off value of 200 ml/min) as a marker of graft function following orthotopic liver transplantation and investigated its relationship with the markers of reperfusion injury during orthotopic liver transplantation.

Methods: In all patients indocyanine green clearance was measured at 24 h. Repeated blood samples were taken before, during the anhepatic and reperfusion phase and up to 12 h following orthotopic liver transplantation to measure the levels of neutrophil elastase and reactive oxygen intermediates. All patients studied had normal hepatic arterial pulse on Doppler-ultrasound post orthotopic liver transplantation.

Results: All patients with indocyanine green clearance >200 ml/min recovered following orthotopic liver transplantation and remained well up to 3 months of follow up. Four patients had an indocyanine green clearance

Conclusion: Indocyanine green reflects the degree of reperfusion injury and is a good early marker of primary graft function. Indocyanine green clearance over 200 ml/min is associated with favorable outcome.

Original languageEnglish
Pages (from-to)142-148
Number of pages7
JournalJournal of Hepatology
Volume30
Issue number1
Publication statusPublished - Jan 1999

Keywords

  • indocyanine green clearance
  • liver transplantation
  • neutrophil elastase
  • reactive oxygen intermediates
  • ISCHEMIA-REPERFUSION
  • ELASTASE
  • ACID
  • COAGULATION
  • INDICATORS
  • MECHANISM
  • DISEASE

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