Induction and transmission of oncogene-induced senescence

Nattaphong Rattanavirotkul, Kristina Kirschner, Tamir Chandra

Research output: Contribution to journalReview articlepeer-review

Abstract

Senescence is a cellular stress response triggered by diverse stressors, including oncogene activation, where it serves as a bona-fide tumour suppressor mechanism. Senescence can be transmitted to neighbouring cells, known as paracrine secondary senescence. Secondary senescence was initially described as a paracrine mechanism, but recent evidence suggests a more complex scenario involving juxtacrine communication between cells. In addition, single-cell studies described differences between primary and secondary senescent end-points, which have thus far not been considered functionally distinct. Here we discuss emerging concepts in senescence transmission and heterogeneity in primary and secondary senescence on a cellular and organ level.

Original languageEnglish
Pages (from-to)843-852
Number of pages10
JournalCellular and Molecular Life Sciences
Volume78
Issue number3
Early online date16 Sep 2020
DOIs
Publication statusPublished - 1 Feb 2021

Keywords

  • Animals
  • CCAAT-Enhancer-Binding Protein-beta/metabolism
  • Cellular Senescence/physiology
  • Humans
  • Jagged-1 Protein/metabolism
  • Oncogenes/genetics
  • Paracrine Communication
  • Receptors, Notch/metabolism
  • Signal Transduction
  • Transforming Growth Factor beta/metabolism

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