Abstract
Although the relationship between hematopoietic stem cells and progenitor populations has been investigated extensively under steady-state conditions, the dynamic response of the hematopoietic compartment during acute infection is largely unknown. Here we show that after infection of mice with Plasmodium chabaudi, a c-Kit(hi) progenitor subset positive for interleukin 7 receptor-alpha (IL-7R alpha) emerged that had both lymphoid and myeloid potential in vitro. After being transferred into uninfected alymphoid or malaria-infected hosts, IL-7R alpha(+)c-Kit(hi) progenitors generated mainly myeloid cells that contributed to the clearance of infected erythrocytes in infected hosts. The generation of these infection-induced progenitors was critically dependent on interferon-gamma (IFN-gamma) signaling in hematopoietic progenitors. Thus, IFN-gamma is a key modulator of hematopoiesis and innate and adaptive immunity during acute malaria infection.
| Original language | English |
|---|---|
| Pages (from-to) | 477-485 |
| Number of pages | 10 |
| Journal | Nature Immunology |
| Volume | 11 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - Jun 2010 |
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Induction of an IL7-R+c-Kithi myelolymphoid progenitor critically dependent on IFN-γ signalling during acute malaria. / Belyaev, Nikolai N.; Brown, Douglas E.; Diaz, Ana-Isabel Garcia et al.
In: Nature Immunology, Vol. 11, No. 6, 06.2010, p. 477-485.Research output: Contribution to journal › Article › peer-review
TY - JOUR
T1 - Induction of an IL7-R+c-Kithi myelolymphoid progenitor critically dependent on IFN-γ signalling during acute malaria
AU - Belyaev, Nikolai N.
AU - Brown, Douglas E.
AU - Diaz, Ana-Isabel Garcia
AU - Rae, Aaron
AU - Jarra, William
AU - Thompson, Joanne
AU - Langhorne, Jean
AU - Potocnik, Alexandre
N1 - Cited By :46 Export Date: 11 March 2015 CODEN: NIAMC Correspondence Address: Potocnik, A. J.; Division of Molecular Immunology, Medical Research Council National Institute for Medical Research, London, United Kingdom; email: apotocn@nimr.mrc.ac.uk Chemicals/CAS: gamma interferon, 82115-62-6; Interferon-gamma, 82115-62-6; Proto-Oncogene Proteins c-kit, 2.7.10.1; Receptors, Interleukin-7 References: Passegué, E., Wagers, A.J., Giuriato, S., Anderson, W.C., Weissman, I.L., Global analysis of proliferation and cell cycle gene expression in the regulation of hematopoietic stem and progenitor cell fates (2005) J. Exp. 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PY - 2010/6
Y1 - 2010/6
N2 - Although the relationship between hematopoietic stem cells and progenitor populations has been investigated extensively under steady-state conditions, the dynamic response of the hematopoietic compartment during acute infection is largely unknown. Here we show that after infection of mice with Plasmodium chabaudi, a c-Kit(hi) progenitor subset positive for interleukin 7 receptor-alpha (IL-7R alpha) emerged that had both lymphoid and myeloid potential in vitro. After being transferred into uninfected alymphoid or malaria-infected hosts, IL-7R alpha(+)c-Kit(hi) progenitors generated mainly myeloid cells that contributed to the clearance of infected erythrocytes in infected hosts. The generation of these infection-induced progenitors was critically dependent on interferon-gamma (IFN-gamma) signaling in hematopoietic progenitors. Thus, IFN-gamma is a key modulator of hematopoiesis and innate and adaptive immunity during acute malaria infection.
AB - Although the relationship between hematopoietic stem cells and progenitor populations has been investigated extensively under steady-state conditions, the dynamic response of the hematopoietic compartment during acute infection is largely unknown. Here we show that after infection of mice with Plasmodium chabaudi, a c-Kit(hi) progenitor subset positive for interleukin 7 receptor-alpha (IL-7R alpha) emerged that had both lymphoid and myeloid potential in vitro. After being transferred into uninfected alymphoid or malaria-infected hosts, IL-7R alpha(+)c-Kit(hi) progenitors generated mainly myeloid cells that contributed to the clearance of infected erythrocytes in infected hosts. The generation of these infection-induced progenitors was critically dependent on interferon-gamma (IFN-gamma) signaling in hematopoietic progenitors. Thus, IFN-gamma is a key modulator of hematopoiesis and innate and adaptive immunity during acute malaria infection.
UR - http://www.scopus.com/inward/record.url?scp=77952581999&partnerID=8YFLogxK
U2 - 10.1038/ni.1869
DO - 10.1038/ni.1869
M3 - Article
VL - 11
SP - 477
EP - 485
JO - Nature Immunology
JF - Nature Immunology
SN - 1529-2908
IS - 6
ER -